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dc.contributor.authorBeyeh, Ngong Kodiah
dc.contributor.authorDíez, Isabel
dc.contributor.authorTaimoory, S. Maryamdokht
dc.contributor.authorMeister, Daniel
dc.contributor.authorFeig, Andrew I.
dc.contributor.authorTrant, John F.
dc.contributor.authorRas, Robin H. A.
dc.contributor.authorRissanen, Kari
dc.date.accessioned2018-03-01T12:25:16Z
dc.date.available2018-03-01T12:25:16Z
dc.date.issued2018
dc.identifier.citationBeyeh, N. K., Díez, I., Taimoory, S. M., Meister, D., Feig, A. I., Trant, J. F., . . . , & Rissanen, K. (2018). High-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor. <em>Chemical Science</em>, 9 (5), 1358-1367. <a href="https://doi.org/10.1039/C7SC05167K">doi:10.1039/C7SC05167K</a>
dc.identifier.otherTUTKAID_76901
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/57222
dc.description.abstractPyrophosphate (PPi) is a byproduct of DNA and RNA synthesis, and abnormal levels are indicative of disease. We report the high-affinity binding of PPi in water by N-alkyl ammonium resorcinarene chloride receptors. Experimental analysis using 1H and 31P NMR, isothermal titration calorimetry, mass spectrometry, and UV-vis spectroscopy all support exceptional selectivity of these systems for PPi in water. The measured affinity of K1 = 1.60 × 107 M−1 for PPi is three orders of magnitude larger than that observed for binding to another phosphate, ATP. This exceptional anion-binding affinity in water is explored through a detailed density functional theory computational study. These systems provide a promising avenue for the development of future innovative medical diagnostic tools.
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofseriesChemical Science
dc.subject.otherpyrophosphate
dc.subject.otherresorcinarenes
dc.subject.otherreceptors
dc.subject.othermolecular diagnostics
dc.titleHigh-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201802281619
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-02-28T13:15:11Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1358-1367
dc.relation.issn2041-6520
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, The Royal Society of Chemistry 2018. This is an open access article distributed under the terms of the Creative Commons License.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by/3.0/
dc.relation.doi10.1039/C7SC05167K


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© the Authors, The Royal Society of Chemistry  2018. This is an open access article distributed under the terms of the Creative Commons License.
Except where otherwise noted, this item's license is described as © the Authors, The Royal Society of Chemistry 2018. This is an open access article distributed under the terms of the Creative Commons License.