Näytä suppeat kuvailutiedot

dc.contributor.authorBeyeh, Ngong Kodiah
dc.contributor.authorDíez, Isabel
dc.contributor.authorTaimoory, S. Maryamdokht
dc.contributor.authorMeister, Daniel
dc.contributor.authorFeig, Andrew I.
dc.contributor.authorTrant, John F.
dc.contributor.authorRas, Robin H. A.
dc.contributor.authorRissanen, Kari
dc.date.accessioned2018-03-01T12:25:16Z
dc.date.available2018-03-01T12:25:16Z
dc.date.issued2018
dc.identifier.citationBeyeh, N. K., Díez, I., Taimoory, S. M., Meister, D., Feig, A. I., Trant, J. F., . . . , & Rissanen, K. (2018). High-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor. <em>Chemical Science</em>, 9 (5), 1358-1367. <a href="https://doi.org/10.1039/C7SC05167K">doi:10.1039/C7SC05167K</a>
dc.identifier.otherTUTKAID_76901
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/57222
dc.description.abstractPyrophosphate (PPi) is a byproduct of DNA and RNA synthesis, and abnormal levels are indicative of disease. We report the high-affinity binding of PPi in water by N-alkyl ammonium resorcinarene chloride receptors. Experimental analysis using 1H and 31P NMR, isothermal titration calorimetry, mass spectrometry, and UV-vis spectroscopy all support exceptional selectivity of these systems for PPi in water. The measured affinity of K1 = 1.60 × 107 M−1 for PPi is three orders of magnitude larger than that observed for binding to another phosphate, ATP. This exceptional anion-binding affinity in water is explored through a detailed density functional theory computational study. These systems provide a promising avenue for the development of future innovative medical diagnostic tools.
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofseriesChemical Science
dc.subject.otherpyrophosphate
dc.subject.otherresorcinarenes
dc.subject.otherreceptors
dc.subject.othermolecular diagnostics
dc.titleHigh-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201802281619
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.identifier.doi10.1039/C7SC05167K
dc.date.updated2018-02-28T13:15:11Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1358-1367
dc.relation.issn2041-6520
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, The Royal Society of Chemistry 2018. This is an open access article distributed under the terms of the Creative Commons License.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by/3.0/


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Näytä suppeat kuvailutiedot

© the Authors, The Royal Society of Chemistry  2018. This is an open access article distributed under the terms of the Creative Commons License.
Ellei muuten mainita, aineiston lisenssi on © the Authors, The Royal Society of Chemistry 2018. This is an open access article distributed under the terms of the Creative Commons License.