Näytä suppeat kuvailutiedot

dc.contributor.authorPekkala, Nina
dc.contributor.authorKnott, Emily
dc.contributor.authorKotiaho, Janne Sakari
dc.contributor.authorPuurtinen, Mikael
dc.date.accessioned2018-02-26T11:26:00Z
dc.date.available2018-02-26T11:26:00Z
dc.date.issued2012
dc.identifier.citationPekkala, N., Knott, E., Kotiaho, J. S., & Puurtinen, M. (2012). Inbreeding rate modifies the dynamics of genetic load in small populations. <em>Ecology and Evolution</em>, 2 (8), 1791-1804. <a href="https://doi.org/10.1002/ece3.293">doi:10.1002/ece3.293</a>
dc.identifier.otherTUTKAID_53391
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/57185
dc.description.abstractThe negative fitness consequences of close inbreeding are widely recognized, but predicting the long-term effects of inbreeding and genetic drift due to limited population size is not straightforward. As the frequency and homozygosity of recessive deleterious alleles increase, selection can remove (purge) them from a population, reducing the genetic load. At the same time, small population size relaxes selection against mildly harmful mutations, which may lead to accumulation of genetic load. The efficiency of purging and the accumulation of mutations both depend on the rate of inbreeding (i.e., population size) and on the nature of mutations. We studied how increasing levels of inbreeding affect offspring production and extinction in experimental Drosophila littoralis populations replicated in two sizes, N = 10 and N = 40. Offspring production and extinction were measured over 25 generations concurrently with a large control population. In the N = 10 populations, offspring production decreased strongly at low levels of inbreeding, then recovered only to show a consistent subsequent decline, suggesting early expression and purging of recessive highly deleterious alleles and subsequent accumulation of mildly harmful mutations. In the N = 40 populations, offspring production declined only after inbreeding reached higher levels, suggesting that inbreeding and genetic drift pose a smaller threat to population fitness when inbreeding is slow. Our results suggest that highly deleterious alleles can be purged in small populations already at low levels of inbreeding, but that purging does not protect the small populations from eventual genetic deterioration and extinction.
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofseriesEcology and Evolution
dc.subject.otherDrosophila littoralis
dc.subject.otherextinction
dc.subject.othergenetic drift
dc.subject.otherinbreeding depression
dc.subject.otheroffspring production
dc.subject.otherpurging
dc.titleInbreeding rate modifies the dynamics of genetic load in small populations
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201802231578
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosThe Department of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.identifier.doi10.1002/ece3.293
dc.date.updated2018-02-23T13:15:03Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1791 1804
dc.relation.issn2045-7758
dc.relation.volume2
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, 2017. Published by Blackwell Publishing Ltd. This is an open access article distributed under the terms of the Creative Commons License.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by-nc/3.0/


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Näytä suppeat kuvailutiedot

© the Authors, 2017. Published by Blackwell Publishing Ltd. This is an open access article distributed under the terms of the Creative Commons License.
Ellei muuten mainita, aineiston lisenssi on © the Authors, 2017. Published by Blackwell Publishing Ltd. This is an open access article distributed under the terms of the Creative Commons License.