Inbreeding rate modifies the dynamics of genetic load in small populations
Pekkala, N., Knott, E., Kotiaho, J. S., & Puurtinen, M. (2012). Inbreeding rate modifies the dynamics of genetic load in small populations. Ecology and Evolution, 2(8), 1791–1804. https://doi.org/10.1002/ece3.293
Published inEcology and Evolution
DisciplineEkologia ja evoluutiobiologiaBiologisten vuorovaikutusten huippututkimusyksikköEvoluutiotutkimus (huippuyksikkö)Ecology and Evolutionary BiologyCentre of Excellence in Biological Interactions ResearchCentre of Excellence in Evolutionary Research
© the Authors, 2017. Published by Blackwell Publishing Ltd. This is an open access article distributed under the terms of the Creative Commons License.
The negative fitness consequences of close inbreeding are widely recognized, but predicting the long-term effects of inbreeding and genetic drift due to limited population size is not straightforward. As the frequency and homozygosity of recessive deleterious alleles increase, selection can remove (purge) them from a population, reducing the genetic load. At the same time, small population size relaxes selection against mildly harmful mutations, which may lead to accumulation of genetic load. The efficiency of purging and the accumulation of mutations both depend on the rate of inbreeding (i.e., population size) and on the nature of mutations. We studied how increasing levels of inbreeding affect offspring production and extinction in experimental Drosophila littoralis populations replicated in two sizes, N = 10 and N = 40. Offspring production and extinction were measured over 25 generations concurrently with a large control population. In the N = 10 populations, offspring production decreased strongly at low levels of inbreeding, then recovered only to show a consistent subsequent decline, suggesting early expression and purging of recessive highly deleterious alleles and subsequent accumulation of mildly harmful mutations. In the N = 40 populations, offspring production declined only after inbreeding reached higher levels, suggesting that inbreeding and genetic drift pose a smaller threat to population fitness when inbreeding is slow. Our results suggest that highly deleterious alleles can be purged in small populations already at low levels of inbreeding, but that purging does not protect the small populations from eventual genetic deterioration and extinction. ...
ISSN Search the Publication Forum2045-7758
Publication in research information system
MetadataShow full item record
Except where otherwise noted, this item's license is described as © the Authors, 2017. Published by Blackwell Publishing Ltd. This is an open access article distributed under the terms of the Creative Commons License.
Showing items with similar title or keywords.
The effects of inbreeding on mating success and offspring production of males and females in a Drosophila littoralis population Laine, Lily (2011)Sisäsiitoksella, eli pariutumisella lähisukulaisten kesken, on monia negatiivisia vaikutuksia sekä populaation että yksilön kelpoisuudelle. Sisäsiitos lisää homotsygotiaa ja mahdollistaa siten väistyvien haitallisten ...
The effects of inbreeding, crossbreeding and stress on metabolic rate in Drosophila littoralis Honkola, Terhi (2009)
Laboratory relationships between adult lifetime reproductive success and fitness surrogates in a Drosophila littoralis population. Pekkala, Nina; Kotiaho, Janne Sakari; Puurtinen, Mikael (Public Library of Science, 2011)The difficulties in measuring total fitness of individuals necessitate the use of fitness surrogates in ecological and evolutionary studies. These surrogates can be different components of fitness (e.g. survival or fecundity), ...