University of Jyväskylä | JYX Digital Repository

  • English  | Give feedback |
    • suomi
    • English
 
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
  • JYX
  • Artikkelit
  • Liikuntatieteiden tiedekunta
  • View Item
JYX > Artikkelit > Liikuntatieteiden tiedekunta > View Item

Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice

ThumbnailFinal Draft
View/Open
332.9 Kb

Downloads:  
Show download detailsHide download details  
Munukka, E., Rintala, A., Toivonen, R., Nylund, M., Yang, B., Takanen, A., Hänninen, A., Vuopio, J., Huovinen, P., Jalkanen, S., & Pekkala, S. (2017). Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice. ISME Journal, 11(7), 1667-1679. https://doi.org/10.1038/ismej.2017.24
Published in
ISME Journal
Authors
Munukka, Eveliina |
Rintala, Anniina |
Toivonen, Raine |
Nylund, Matts |
Yang, Baoru |
Takanen, Anna |
Hänninen, Arno |
Vuopio, Jaana |
Huovinen, Pentti |
Jalkanen, Sirpa |
Pekkala, Satu
Date
2017
Discipline
LiikuntalääketiedeSports and Exercise Medicine
Copyright
© the Authors, 2017. This is a final draft version of an article whose final and definitive form has been published by Nature Publishing Group. Published in this repository with the kind permission of the publisher.

 
Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters. Adiponectin expression was increased in the visceral adipose tissue, and the subcutaneous and visceral adipose tissues were more insulin sensitive and less inflamed in F. prausnitzii-treated mice. Further, F. prausnitzii treatment increased muscle mass that may be linked to enhanced mitochondrial respiration, modified gut microbiota composition and improved intestinal integrity. Our findings show that F. prausnitzii treatment improves hepatic health, and decreases adipose tissue inflammation in mice and warrant the need for further studies to discover its therapeutic potential. ...
Publisher
Nature Publishing Group
ISSN Search the Publication Forum
1751-7362
Keywords
gut microbiota Faecalibacterium prausnitzii hepatic health adipose tissue inflammation
DOI
https://doi.org/10.1038/ismej.2017.24
URI

http://urn.fi/URN:NBN:fi:jyu-201801291354

Publication in research information system

https://converis.jyu.fi/converis/portal/detail/Publication/26937899

Metadata
Show full item record
Collections
  • Liikuntatieteiden tiedekunta [2095]

Related items

Showing items with similar title or keywords.

  • Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats 

    Lensu, Sanna; Waselius, Tomi; Mäkinen, Elina; Kettunen, Heikki; Virtanen, Ari; Tiirola, Marja; Penttonen, Markku; Pekkala, Satu; Nokia, Miriam S. (Wiley-Blackwell, 2021)
    Treatment of brain cancer, glioma, can cause cognitive impairment as a side‐effect, possibly because it disrupts the integrity of the hippocampus, a structure vital for normal memory. Radiotherapy is commonly used to treat ...
  • Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation : Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering 

    Hintikka, Jukka; Lensu, Sanna; Mäkinen, Elina; Karvinen, Sira; Honkanen, Marjaana; Lindén, Jere; Garrels, Tim; Pekkala, Satu; Lahti, Leo (MDPI AG, 2021)
    We have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We ...
  • Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis 

    Toivonen, Raine; Vanhatalo, Sanja; Hollmén, Maija; Munukka, Eveliina; Keskitalo, Anniina; Pietilä, Sami; Elo, Laura; Huovinen, Pentti; Jalkanen, Sirpa; Pekkala, Satu (MDPI, 2021)
    Toll-like receptor 5 ligand, flagellin, and Vascular Adhesion Protein-1 (VAP-1) are involved in non-alcoholic fatty liver disease (NAFLD). This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat ...
  • Should inflammatory pathways be targeted for the prevention and treatment of hypertension? 

    Kunutsor, Setor K.; Laukkanen, Jari (BMJ, 2019)
    Hypertension is the most common modifiable risk factor for cardiovascular disease (CVD)1 and is a leading cause of death globally.2 Hypertension and CVD share common antecedent risk factors which include physical inactivity, ...
  • Exercise Medicine for Cancer Cachexia : Targeted Exercise to Counteract Mechanisms and Treatment Side Effects 

    Mavropalias, Georgios; Sim, Marc; Taaffe, Dennis, R.; Galvão, Daniel A.; Spry, Nigel; Kraemer, William, J.; Häkkinen, Keijo; Newton, Robert, U. (Springer Science and Business Media LLC, 2022)
    Purpose -- Cancer-induced muscle wasting (i.e., cancer cachexia, CC) is a common and devastating syndrome that results in the death of more than 1 in 5 patients. Although primarily a result of elevated inflammation, there ...
  • Browse materials
  • Browse materials
  • Articles
  • Conferences and seminars
  • Electronic books
  • Historical maps
  • Journals
  • Tunes and musical notes
  • Photographs
  • Presentations and posters
  • Publication series
  • Research reports
  • Research data
  • Study materials
  • Theses

Browse

All of JYXCollection listBy Issue DateAuthorsSubjectsPublished inDepartmentDiscipline

My Account

Login

Statistics

View Usage Statistics
  • How to publish in JYX?
  • Self-archiving
  • Publish Your Thesis Online
  • Publishing Your Dissertation
  • Publication services

Open Science at the JYU
 
Data Protection Description

Accessibility Statement

Unless otherwise specified, publicly available JYX metadata (excluding abstracts) may be freely reused under the CC0 waiver.
Open Science Centre