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dc.contributor.authorLaanto, Elina
dc.contributor.authorHoikkala, Ville
dc.contributor.authorRavantti, Janne
dc.contributor.authorSundberg, Lotta-Riina
dc.date.accessioned2017-08-14T06:10:22Z
dc.date.available2017-08-14T06:10:22Z
dc.date.issued2017
dc.identifier.citationLaanto, E., Hoikkala, V., Ravantti, J., & Sundberg, L.-R. (2017). Long-term genomic coevolution of host-parasite interaction in the natural environment. <i>Nature Communications</i>, <i>8</i>, Article 111. <a href="https://doi.org/10.1038/s41467-017-00158-7" target="_blank">https://doi.org/10.1038/s41467-017-00158-7</a>
dc.identifier.otherCONVID_27136784
dc.identifier.otherTUTKAID_74542
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/55080
dc.description.abstractAntagonistic coevolution of parasite infectivity and host resistance may alter the biological functionality of species, yet these dynamics in nature are still poorly understood. Here we show the molecular details of a long-term phage–bacterium arms race in the environment. Bacteria (Flavobacterium columnare) are generally resistant to phages from the past and susceptible to phages isolated in years after bacterial isolation. Bacterial resistance selects for increased phage infectivity and host range, which is also associated with expansion of phage genome size. We identified two CRISPR loci in the bacterial host: a type II-C locus and a type VI-B locus. While maintaining a core set of conserved spacers, phage-matching spacers appear in the variable ends of both loci over time. The spacers mostly target the terminal end of the phage genomes, which also exhibit the most variation across time, resulting in arms-race-like changes in the protospacers of the coevolving phage population.
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesNature Communications
dc.subject.otherbakteerit
dc.subject.otherbakteriofagit
dc.subject.otherevoluutio
dc.subject.othergenomiikka
dc.subject.otherresistenssi
dc.subject.otherbacteria
dc.subject.otherbacteriophages
dc.subject.otherevolution
dc.subject.othergenomics
dc.subject.otherresistance (medicine)
dc.titleLong-term genomic coevolution of host-parasite interaction in the natural environment
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201707273367
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineBiologisten vuorovaikutusten huippututkimusyksikköfi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.contributor.oppiaineCentre of Excellence in Biological Interactions Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-07-27T15:15:05Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn2041-1723
dc.relation.numberinseries0
dc.relation.volume8
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, 2017. This is an open access article licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysobakteerit
dc.subject.ysobakteriofagit
dc.subject.ysoevoluutio
dc.subject.ysogenomiikka
dc.subject.ysoresistenssi
jyx.subject.urihttp://www.yso.fi/onto/yso/p1749
jyx.subject.urihttp://www.yso.fi/onto/yso/p25303
jyx.subject.urihttp://www.yso.fi/onto/yso/p8278
jyx.subject.urihttp://www.yso.fi/onto/yso/p5146
jyx.subject.urihttp://www.yso.fi/onto/yso/p16107
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41467-017-00158-7


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© the Authors, 2017. This is an open access article licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as © the Authors, 2017. This is an open access article licensed under a Creative Commons Attribution 4.0 International License.