Long-term genomic coevolution of host-parasite interaction in the natural environment
Laanto, E., Hoikkala, V., Ravantti, J., & Sundberg, L.-R. (2017). Long-term genomic coevolution of host-parasite interaction in the natural environment. Nature Communications, 8, Article 111. https://doi.org/10.1038/s41467-017-00158-7
Published inNature Communications
DisciplineSolu- ja molekyylibiologiaBiologisten vuorovaikutusten huippututkimusyksikköCell and Molecular BiologyCentre of Excellence in Biological Interactions Research
© the Authors, 2017. This is an open access article licensed under a Creative Commons Attribution 4.0 International License.
Antagonistic coevolution of parasite infectivity and host resistance may alter the biological functionality of species, yet these dynamics in nature are still poorly understood. Here we show the molecular details of a long-term phage–bacterium arms race in the environment. Bacteria (Flavobacterium columnare) are generally resistant to phages from the past and susceptible to phages isolated in years after bacterial isolation. Bacterial resistance selects for increased phage infectivity and host range, which is also associated with expansion of phage genome size. We identified two CRISPR loci in the bacterial host: a type II-C locus and a type VI-B locus. While maintaining a core set of conserved spacers, phage-matching spacers appear in the variable ends of both loci over time. The spacers mostly target the terminal end of the phage genomes, which also exhibit the most variation across time, resulting in arms-race-like changes in the protospacers of the coevolving phage population.
PublisherNature Publishing Group
Publication in research information system
MetadataShow full item record
Except where otherwise noted, this item's license is described as © the Authors, 2017. This is an open access article licensed under a Creative Commons Attribution 4.0 International License.
Showing items with similar title or keywords.
Hoikkala, Ville; Ravantti, Janne; Díez-Villaseñor, César; Tiirola, Marja; Conrad, Rachel A.; McBride, Mark J.; Moineau, Sylvain; Sundberg, Lotta-Riina (American Society for Microbiology, 2021)CRISPR-Cas immune systems adapt to new threats by acquiring new spacers from invading nucleic acids such as phage genomes. However, some CRISPR-Cas loci lack genes necessary for spacer acquisition despite variation in ...
Saarinen, Kati (University of Jyväskylä, 2016)The consequences of the climate change on species are still uncertain, despite of intensive research. Currently, rising temperature is not the only concern, since the climate change scenarios also predict increases in ...
Mattila, Sari (University of Jyväskylä, 2016)Viruses and plasmids are small units of genetic material dependent on cells either transiently or continuously. Intriguingly, stories of these small entities intertwine in antibiotic resistance crisis. Horizontal gene ...
Protist predation can select for bacteria with lowered susceptibility to infection by lytic phages Örmälä, Anni-Maria; Ojala, Ville; Hiltunen, Teppo; Zhang, Ji; Bamford, Jaana; Laakso, Jouni (BioMed Central Ltd., 2015)Background: Consumer-resource interactions constitute one of the most common types of interspecific antagonistic interaction. In natural communities, complex species interactions are likely to affect the outcomes of ...
Extending the hosts of Tectiviridae into four additional genera of Gram-positive bacteria and more diverse Bacillus species Jalasvuori, Matti; Koskinen, Katariina (Academic Press, 2018)Tectiviridae are composed of tailless bacteriophages with an icosahedral capsid and an inner membrane enclosing a double-stranded 15 kb linear DNA genome. Five of the seven previously studied Tectivirus isolates infect ...