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dc.contributor.authorNokia, Miriam
dc.contributor.authorGureviciene, Irina
dc.contributor.authorWaselius, Tomi
dc.contributor.authorTanila, Heikki
dc.contributor.authorPenttonen, Markku
dc.date.accessioned2017-08-02T11:53:41Z
dc.date.available2018-05-23T21:35:40Z
dc.date.issued2017
dc.identifier.citationNokia, M., Gureviciene, I., Waselius, T., Tanila, H., & Penttonen, M. (2017). Hippocampal electrical stimulation disrupts associative learning when targeted at dentate spikes. <i>Journal of Physiology</i>, <i>595</i>(14), 4961-4971. <a href="https://doi.org/10.1113/JP274023" target="_blank">https://doi.org/10.1113/JP274023</a>
dc.identifier.otherCONVID_26965554
dc.identifier.otherTUTKAID_73577
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/54982
dc.description.abstractHippocampal electrophysiological oscillations, namely theta and ripples, have been implicated in encoding and consolidation of new memories, respectively. According to existing literature, hippocampal dentate spikes are prominent, short‐duration (<30 ms), large‐amplitude (∼2–4 mV) fluctuations in hilar local‐field potentials that take place during awake immobility and sleep. Interestingly, previous studies indicate that during dentate spikes dentate gyrus granule cells increase their firing while firing of CA1 pyramidal cells are suppressed, thus resulting in momentary uncoupling of the two hippocampal subregions. To date, the behavioural significance of dentate spikes is unknown. Here, to study the possible role of dentate spikes in learning, we trained adult male Sprague–Dawley rats in trace eyeblink classical conditioning. For 1 h immediately following each conditioning session, one group of animals received hippocampal stimulation via the ventral hippocampal commissure (vHC) contingent on dentate spikes to disrupt the uncoupling between the dentate gyrus and the CA1 subregions. A yoked control group was stimulated during immobility, irrespective of brain state, and another control group was not stimulated at all. As a result, learning was impaired only in the group where vHC stimulation was administered contingent on dentate spikes. Our results suggest dentate spikes and/or the associated uncoupling of the dentate gyrus and the CA1 play a significant role in memory consolidation. Dentate spikes could possibly reflect reactivation and refinement of a memory trace within the dentate gyrus triggered by input from the entorhinal cortex.en
dc.language.isoeng
dc.publisherBlackwell
dc.relation.ispartofseriesJournal of Physiology
dc.subject.otherhippocampal electrical stimulation
dc.subject.otherassociative learning
dc.subject.otherdentate spikes
dc.titleHippocampal electrical stimulation disrupts associative learning when targeted at dentate spikes
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201707193330
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-07-19T12:15:05Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange4961-4971
dc.relation.issn0022-3751
dc.relation.numberinseries14
dc.relation.volume595
dc.type.versionacceptedVersion
dc.rights.copyright© 2017 The Authors. The Journal of Physiology © 2017 The Physiological Society. This is a final draft version of an article whose final and definitive form has been published by Blackwell. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber286384
dc.relation.grantnumber275954
dc.relation.grantnumber284155
dc.subject.ysohippokampus
jyx.subject.urihttp://www.yso.fi/onto/yso/p21117
dc.relation.doi10.1113/JP274023
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundinginformationThis study was supported by the Academy of Finland (grant no. 139767 to M.P. and grant nos. 275954, 284155 and 286384 to M.S.N.).
dc.type.okmA1


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