dc.contributor.author | Finni Juutinen, Taija | |
dc.contributor.author | Noorkoiv, Marika | |
dc.contributor.author | Laakkonen, Eija | |
dc.contributor.author | Ronkainen, Paula | |
dc.contributor.author | Alen, Markku | |
dc.contributor.author | Kaprio, Jaakko | |
dc.contributor.author | Kovanen, Vuokko | |
dc.contributor.author | Sipilä, Sarianna | |
dc.date.accessioned | 2017-05-18T07:29:28Z | |
dc.date.available | 2017-05-18T07:29:28Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Finni Juutinen, T., Noorkoiv, M., Laakkonen, E., Ronkainen, P., Alen, M., Kaprio, J., Kovanen, V., & Sipilä, S. (2011). Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy.. <i>Muscle & Nerve</i>, <i>44</i>(5), 769-775. <a href="https://doi.org/10.1002/mus.22162" target="_blank">https://doi.org/10.1002/mus.22162</a> | |
dc.identifier.other | CONVID_20601021 | |
dc.identifier.other | TUTKAID_45797 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/54015 | |
dc.description.abstract | Introduction: Postmenopausal monozygotic twin pairs discordant for hormone replacement therapy (HRT) provide an advantageous study design controlling for genetic background for elucidating the relationships between aging, sex hormone levels, muscle strength, contractile capacity, and fatigability. Methods: Thirteen postmenopausal monozygotic twin pairs discordant for HRT were measured for maximal voluntary torque (MVC) and twitch characteristics using electrical stimulation before and after intermittent dynamic plantarflexor exercise until exhaustion. Results: Peak twitch torque was 32% higher in HRT users than in their non-HRT, genetically identical sisters (P = 0.002), but MVC did not differ. There were no differences in the activation level or twitch time characteristics between the co-twins. Fatigue caused decreases in MVC (P = 0.001), twitch torque (P = 0.001), time to peak (P = 0.013), and half-relaxation time (P = 0.001) similarly in HRT users and non–HRT users. Conclusion: In early postmenopausal women, involuntary but not voluntary force-generating mechanisms of the plantarflexors are augmented by the use of HRT. | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofseries | Muscle & Nerve | |
dc.subject.other | estrogeeni | |
dc.subject.other | väsyminen | |
dc.subject.other | strength | |
dc.subject.other | twitch | |
dc.subject.other | fatigue | |
dc.subject.other | plantarflexor | |
dc.title | Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy. | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201705082228 | |
dc.contributor.laitos | Liikuntabiologian laitos | fi |
dc.contributor.laitos | Terveystieteiden laitos | fi |
dc.contributor.laitos | Department of Biology of Physical Activity | en |
dc.contributor.laitos | Department of Health Sciences | en |
dc.contributor.oppiaine | Biomekaniikka | fi |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Biomechanics | en |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.contributor.oppiaine | Gerontology Research Center | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2017-05-08T12:15:08Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 769-775 | |
dc.relation.issn | 0148-639X | |
dc.relation.numberinseries | 5 | |
dc.relation.volume | 44 | |
dc.type.version | acceptedVersion | |
dc.rights.copyright | © 2011 Wiley Periodicals, Inc. This is a final draft version of an article whose final and definitive form has been published by Wiley. Published in this repository with the kind permission of the publisher. | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | voima | |
dc.subject.yso | estradioli | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5039 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p19425 | |
dc.relation.doi | 10.1002/mus.22162 | |
dc.type.okm | A1 | |