Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy.
Finni Juutinen, T., Noorkoiv, M., Laakkonen, E., Ronkainen, P., Alen, M., Kaprio, J., Kovanen, V., & Sipilä, S. (2011). Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy.. Muscle & Nerve, 44(5), 769-775. https://doi.org/10.1002/mus.22162
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Muscle & NerveAuthors
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2011Discipline
BiomekaniikkaGerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöBiomechanicsGerontology and Public HealthGerontology Research CenterSchool of WellbeingCopyright
© 2011 Wiley Periodicals, Inc. This is a final draft version of an article whose final and definitive form has been published by Wiley. Published in this repository with the kind permission of the publisher.
Introduction: Postmenopausal monozygotic twin pairs discordant for hormone replacement therapy (HRT) provide an advantageous study design controlling for genetic background for elucidating the relationships between aging, sex hormone levels, muscle strength, contractile capacity, and fatigability. Methods: Thirteen postmenopausal monozygotic twin pairs discordant for HRT were measured for maximal voluntary torque (MVC) and twitch characteristics using electrical stimulation before and after intermittent dynamic plantarflexor exercise until exhaustion. Results: Peak twitch torque was 32% higher in HRT users than in their non-HRT, genetically identical sisters (P = 0.002), but MVC did not differ. There were no differences in the activation level or twitch time characteristics between the co-twins. Fatigue caused decreases in MVC (P = 0.001), twitch torque (P = 0.001), time to peak (P = 0.013), and half-relaxation time (P = 0.001) similarly in HRT users and non–HRT users. Conclusion: In early postmenopausal women, involuntary but not voluntary force-generating mechanisms of the plantarflexors are augmented by the use of HRT.
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