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dc.contributor.authorKarvinen, Sira
dc.contributor.authorSilvennoinen, Mika
dc.contributor.authorMa, Hongqiang
dc.contributor.authorTörmäkangas, Timo
dc.contributor.authorRantalainen, Timo
dc.contributor.authorRinnankoski-Tuikka, Rita
dc.contributor.authorLensu, Sanna
dc.contributor.authorKoch, Lauren G.
dc.contributor.authorBritton, Steven L.
dc.contributor.authorKainulainen, Heikki
dc.date.accessioned2016-08-24T08:13:14Z
dc.date.available2016-08-24T08:13:14Z
dc.date.issued2016
dc.identifier.citationKarvinen, S., Silvennoinen, M., Ma, H., Törmäkangas, T., Rantalainen, T., Rinnankoski-Tuikka, R., . . . Kainulainen, H. (2016). Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. <em>Frontiers in Physiology</em>, 7, 311. <a href="http://dx.doi.org/10.3389/fphys.2016.00311">doi:10.3389/fphys.2016.00311</a>
dc.identifier.otherTUTKAID_70893
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/51030
dc.description.abstractThe production of heat, i.e., thermogenesis, is a significant component of the metabolic rate, which in turn affects weight gain and health. Thermogenesis is linked to physical activity (PA) level. However, it is not known whether intrinsic exercise capacity, aging, and long-term voluntary running affect core body temperature. Here we use rat models selectively bred to differ in maximal treadmill endurance running capacity (Low capacity runners, LCR and High capacity Runners, HCR), that as adults are divergent for aerobic exercise capacity, aging, and metabolic disease risk to study the connection between PA and body temperature. Ten high capacity runner (HCR) and ten low capacity runner (LCR) female rats were studied between 9 and 21 months of age. Rectal body temperature of HCR and LCR rats was measured before and after 1-year voluntary running/control intervention to explore the effects of aging and PA. Also, we determined whether injected glucose and spontaneous activity affect the body temperature differently between LCR and HCR rats at 9 vs. 21 months of age. HCRs had on average 1.3◦C higher body temperature than LCRs (p < 0.001). Aging decreased the body temperature level of HCRs to similar levels with LCRs. The opportunity to run voluntarily had a significant impact on the body temperature of HCRs (p < 0.001) allowing them to maintain body temperature at a similar level as when at younger age. Compared to LCRs, HCRs were spontaneously more active, had higher relative gastrocnemius muscle mass and higher UCP2, PGC-1α, cyt c, and OXPHOS levels in the skeletal muscle (p < 0.050). These results suggest that higher PA level together with greater relative muscle mass and higher mitochondrial content/function contribute to the accumulation of heat in the HCRs. Interestingly, neither aging nor voluntary training had a significant impact on core body temperature of LCRs. However, glucose injection resulted in a lowering of the body temperature of LCRs (p < 0.050), but not that of HCRs. In conclusion, rats born with high intrinsic capacity for aerobic exercise and better health have higher body temperature compared to rats born with low exercise capacity and disease risk. Voluntary running allowed HCRs to maintain high body temperature during aging, which suggests that high PA level was crucial in maintaining the high body temperature of HCRs.
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofseriesFrontiers in Physiology
dc.subject.otheraerobic capacity
dc.subject.otheraging
dc.subject.otherbody temperature
dc.subject.otherphysical activity
dc.subject.otherskeletal muscle
dc.titleVoluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201608153796
dc.contributor.laitosLiikuntabiologian laitosfi
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Biology of Physical Activityen
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologia
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.contributor.oppiaineLiikuntalääketiede
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-08-15T09:15:11Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn1664-042X
dc.relation.volume7
dc.type.versionpublishedVersion
dc.rights.copyright© 2016 the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fphys.2016.00311


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© 2016 the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Except where otherwise noted, this item's license is described as © 2016 the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).