Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity
Karvinen, S., Silvennoinen, M., Ma, H., Törmäkangas, T., Rantalainen, T., Rinnankoski-Tuikka, R., Lensu, S., Koch, L. G., Britton, S. L., & Kainulainen, H. (2016). Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. Frontiers in Physiology, 7, Article 311. https://doi.org/10.3389/fphys.2016.00311
Published inFrontiers in Physiology
DisciplineLiikuntafysiologiaGerontologia ja kansanterveysLiikuntalääketiedeExercise PhysiologyGerontology and Public HealthSports and Exercise Medicine
© 2016 the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
The production of heat, i.e., thermogenesis, is a significant component of the metabolic rate, which in turn affects weight gain and health. Thermogenesis is linked to physical activity (PA) level. However, it is not known whether intrinsic exercise capacity, aging, and long-term voluntary running affect core body temperature. Here we use rat models selectively bred to differ in maximal treadmill endurance running capacity (Low capacity runners, LCR and High capacity Runners, HCR), that as adults are divergent for aerobic exercise capacity, aging, and metabolic disease risk to study the connection between PA and body temperature. Ten high capacity runner (HCR) and ten low capacity runner (LCR) female rats were studied between 9 and 21 months of age. Rectal body temperature of HCR and LCR rats was measured before and after 1-year voluntary running/control intervention to explore the effects of aging and PA. Also, we determined whether injected glucose and spontaneous activity affect the body temperature differently between LCR and HCR rats at 9 vs. 21 months of age. HCRs had on average 1.3◦C higher body temperature than LCRs (p < 0.001). Aging decreased the body temperature level of HCRs to similar levels with LCRs. The opportunity to run voluntarily had a significant impact on the body temperature of HCRs (p < 0.001) allowing them to maintain body temperature at a similar level as when at younger age. Compared to LCRs, HCRs were spontaneously more active, had higher relative gastrocnemius muscle mass and higher UCP2, PGC-1α, cyt c, and OXPHOS levels in the skeletal muscle (p < 0.050). These results suggest that higher PA level together with greater relative muscle mass and higher mitochondrial content/function contribute to the accumulation of heat in the HCRs. Interestingly, neither aging nor voluntary training had a significant impact on core body temperature of LCRs. However, glucose injection resulted in a lowering of the body temperature of LCRs (p < 0.050), but not that of HCRs. In conclusion, rats born with high intrinsic capacity for aerobic exercise and better health have higher body temperature compared to rats born with low exercise capacity and disease risk. Voluntary running allowed HCRs to maintain high body temperature during aging, which suggests that high PA level was crucial in maintaining the high body temperature of HCRs. ...
PublisherFrontiers Research Foundation
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Except where otherwise noted, this item's license is described as © 2016 the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Showing items with similar title or keywords.
Lifespan and skeletal muscle properties the effects of genetic background, physical activity and aging Karvinen, Sira (University of Jyväskylä, 2016)Obesity and metabolic disorders have become a notable world-wide epidemic. The pathogenesis of metabolic diseases, such as metabolic syndrome and type 2 diabetes, has begun to negatively affect life expectancy of current ...
Effects of chemotherapy and blocking activin receptor signaling on skeletal muscle size, oxidative capacity and function Poikonen, Aino (2016)Introduction. Doxorubicin (DOX) is widely used as a chemotherapy drug for cancer. However, it is known to affect negatively skeletal muscle mass and function, which can expose to other diseases and decrease survival rate. ...
Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue Zhuang, Haihui; Karvinen, Sira; Törmäkangas, Timo; Zhang, Xiaobo; Ojanen, Xiaowei; Velagapudi, Vidya; Alen, Markku; Britton, Steven L.; Koch, Lauren G.; Kainulainen, Heikki; Cheng, Sulin; Wiklund, Petri (Springer, 2021)Aerobic capacity is a strong predictor of longevity. With aging, aerobic capacity decreases concomitantly with changes in whole body metabolism leading to increased disease risk. To address the role of aerobic capacity, ...
Associations of physical performance and physical activity with mental well-being in middle-aged women Bondarev, Dmitriy; Sipilä, Sarianna; Finni, Taija; Kujala, Urho M.; Aukee, Pauliina; Kovanen, Vuokko; Laakkonen, Eija; Kokko, Katja (Biomed Central, 2021)Background To investigate whether physical performance is independently of physical activity (PA) associated with positive and negative dimensions of mental well-being in middle-aged women. Methods Data were drawn ...
Effects of Repeated Sprint Training in Hypoxia on Physical Performance Among Athletes : A Systematic Review Zelenovic, Milan; Kontro, Titta; Stojanovic, Tijana; Alexe, Dan Iulian; Bozic, Danijel; Aksovic, Nikola; Bjelica, Bojan; Milanovic, Zoran; Adrian, Sava Mihai (SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2021)Repeated sprint training in hypoxia (RSH) represents an innovative method in the process of development and improvement of physical performance among athletes. However, there is less scientific data on this topic. The ...