dc.contributor.author | Vehniäinen, Eeva-Riikka | |
dc.contributor.author | Vähäkangas, Kirsi | |
dc.contributor.author | Oikari, Aimo | |
dc.date.accessioned | 2016-08-10T13:04:38Z | |
dc.date.available | 2016-08-10T13:04:38Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Vehniäinen, E.-R., Vähäkangas, K., & Oikari, A. (2012). UV-B Exposure Causes DNA Damage and Changes in Protein Expression in Northern Pike (Esox lucius) Posthatched Embryos. <i>Photochemistry and Photobiology</i>, <i>88</i>(2), 363-370. <a href="https://doi.org/10.1111/j.1751-1097.2011.01058.x" target="_blank">https://doi.org/10.1111/j.1751-1097.2011.01058.x</a> | |
dc.identifier.other | CONVID_21520360 | |
dc.identifier.other | TUTKAID_51244 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/50923 | |
dc.description.abstract | The ongoing anthropogenically caused ozone depletion and
climate change has increased the amount of biologically harmful
UV-B radiation, which is detrimental to fish in embryonal stages.
The effects of UV-B radiation on the levels and locations of
DNA damage manifested as cyclobutane pyrimidine dimers
(CPDs), heat shock protein 70 (HSP70) and p53 protein in
newly hatched embryos of pike were examined. Pike larvae were
exposed in the laboratory to current and enhanced doses of
UV-B radiation. UV-B exposure caused the formation of CPDs
in a fluence rate-dependent manner, and the CPDs were found
deeper in the tissues with increasing fluence rates. UV-B radiation
induced HSP70 in epidermis, and caused plausible p53 activation
in the brain and epidermis of some individuals. Also at a fluence
rate occurring in nature, the DNA damage in the brain and eyes
of pike and changes in protein expression were followed by severe
behavioral disorders, suggesting that neural molecular changes
were associated with functional consequences. | |
dc.language.iso | eng | |
dc.publisher | John Wiley & Sons | |
dc.relation.ispartofseries | Photochemistry and Photobiology | |
dc.relation.uri | http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01058.x/full | |
dc.subject.other | ultravioletti-B-säteily | |
dc.subject.other | DNA-vauriot | |
dc.subject.other | HSP70 | |
dc.subject.other | p53 | |
dc.subject.other | kalan alkiopoikaset | |
dc.subject.other | ultraviolet-B | |
dc.subject.other | DNA damage | |
dc.subject.other | fish embryos | |
dc.subject.other | Northern pike | |
dc.title | UV-B Exposure Causes DNA Damage and Changes in Protein Expression in Northern Pike (Esox lucius) Posthatched Embryos | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201206121847 | |
dc.contributor.laitos | Bio- ja ympäristötieteiden laitos | fi |
dc.contributor.laitos | Department of Biological and Environmental Science | en |
dc.contributor.oppiaine | Ympäristötiede | fi |
dc.contributor.oppiaine | Environmental Science | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2012-06-12T03:30:04Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 363-370 | |
dc.relation.issn | 0031-8655 | |
dc.relation.numberinseries | 2 | |
dc.relation.volume | 88 | |
dc.type.version | acceptedVersion | |
dc.rights.copyright | © Wiley. This is a final draft version of an article whose final and definitive version has been published by Wiley. | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | hauki | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p10048 | |
dc.relation.doi | 10.1111/j.1751-1097.2011.01058.x | |
dc.type.okm | A1 | |