Näytä suppeat kuvailutiedot

dc.contributor.authorVehniäinen, Eeva-Riikka
dc.contributor.authorVähäkangas, Kirsi
dc.contributor.authorOikari, Aimo
dc.date.accessioned2016-08-10T13:04:38Z
dc.date.available2016-08-10T13:04:38Z
dc.date.issued2012
dc.identifier.citationVehniäinen, E.-R., Vähäkangas, K., & Oikari, A. (2012). UV-B Exposure Causes DNA Damage and Changes in Protein Expression in Northern Pike (Esox lucius) Posthatched Embryos. <i>Photochemistry and Photobiology</i>, <i>88</i>(2), 363-370. <a href="https://doi.org/10.1111/j.1751-1097.2011.01058.x" target="_blank">https://doi.org/10.1111/j.1751-1097.2011.01058.x</a>
dc.identifier.otherCONVID_21520360
dc.identifier.otherTUTKAID_51244
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/50923
dc.description.abstractThe ongoing anthropogenically caused ozone depletion and climate change has increased the amount of biologically harmful UV-B radiation, which is detrimental to fish in embryonal stages. The effects of UV-B radiation on the levels and locations of DNA damage manifested as cyclobutane pyrimidine dimers (CPDs), heat shock protein 70 (HSP70) and p53 protein in newly hatched embryos of pike were examined. Pike larvae were exposed in the laboratory to current and enhanced doses of UV-B radiation. UV-B exposure caused the formation of CPDs in a fluence rate-dependent manner, and the CPDs were found deeper in the tissues with increasing fluence rates. UV-B radiation induced HSP70 in epidermis, and caused plausible p53 activation in the brain and epidermis of some individuals. Also at a fluence rate occurring in nature, the DNA damage in the brain and eyes of pike and changes in protein expression were followed by severe behavioral disorders, suggesting that neural molecular changes were associated with functional consequences.
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.ispartofseriesPhotochemistry and Photobiology
dc.relation.urihttp://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01058.x/full
dc.subject.otherultravioletti-B-säteily
dc.subject.otherDNA-vauriot
dc.subject.otherHSP70
dc.subject.otherp53
dc.subject.otherkalan alkiopoikaset
dc.subject.otherultraviolet-B
dc.subject.otherDNA damage
dc.subject.otherfish embryos
dc.subject.otherNorthern pike
dc.titleUV-B Exposure Causes DNA Damage and Changes in Protein Expression in Northern Pike (Esox lucius) Posthatched Embryos
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201206121847
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineYmpäristötiedefi
dc.contributor.oppiaineEnvironmental Scienceen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2012-06-12T03:30:04Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange363-370
dc.relation.issn0031-8655
dc.relation.numberinseries2
dc.relation.volume88
dc.type.versionacceptedVersion
dc.rights.copyright© Wiley. This is a final draft version of an article whose final and definitive version has been published by Wiley.
dc.rights.accesslevelopenAccessfi
dc.subject.ysohauki
jyx.subject.urihttp://www.yso.fi/onto/yso/p10048
dc.relation.doi10.1111/j.1751-1097.2011.01058.x
dc.type.okmA1


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Näytä suppeat kuvailutiedot