UV-B Exposure Causes DNA Damage and Changes in Protein Expression in Northern Pike (Esox lucius) Posthatched Embryos
Vehniäinen, E.-R., Vähäkangas, K., & Oikari, A. (2012). UV-B Exposure Causes DNA Damage and Changes in Protein Expression in Northern Pike (Esox lucius) Posthatched Embryos. Photochemistry and Photobiology, 88(2), 363-370. https://doi.org/10.1111/j.1751-1097.2011.01058.x
Published inPhotochemistry and Photobiology
© Wiley. This is a final draft version of an article whose final and definitive version has been published by Wiley.
The ongoing anthropogenically caused ozone depletion and climate change has increased the amount of biologically harmful UV-B radiation, which is detrimental to fish in embryonal stages. The effects of UV-B radiation on the levels and locations of DNA damage manifested as cyclobutane pyrimidine dimers (CPDs), heat shock protein 70 (HSP70) and p53 protein in newly hatched embryos of pike were examined. Pike larvae were exposed in the laboratory to current and enhanced doses of UV-B radiation. UV-B exposure caused the formation of CPDs in a fluence rate-dependent manner, and the CPDs were found deeper in the tissues with increasing fluence rates. UV-B radiation induced HSP70 in epidermis, and caused plausible p53 activation in the brain and epidermis of some individuals. Also at a fluence rate occurring in nature, the DNA damage in the brain and eyes of pike and changes in protein expression were followed by severe behavioral disorders, suggesting that neural molecular changes were associated with functional consequences. ...
PublisherJohn Wiley & Sons
Publication in research information system
MetadataShow full item record
Showing items with similar title or keywords.
Fluence rate or cumulative dose? : Vulnerability of larval northern pike (Esox lucius) to ultraviolet radiation Vehniäinen, Eeva-Riikka; Häkkinen, Jani; Oikari, Aimo (Wiley-Blackwell Publishing, Inc.; American Society for Photobiology, 2007)Newly hatched larvae of northern pike were exposed in the laboratory to four fluence rates of ultraviolet radiation (UVR; 290–400 nm) over three different time periods, resulting in total doses ranging from 3.0 ± 0.2 to ...
Vehniäinen, Eeva-Riikka; Häkkinen, Jani; Oikari, Aimo (2007)Ultraviolet radiation (UVR)-induced mortality and behavioural disorder were studied in larval northern pike of two origins and ages. Newly hatched larvae of two differently coloured populations and six-day-old larvae of ...
Mercury accumulation in the northern pike (Esox lucius) and its intestinal parasite, Triaenophorus nodulosus (Cestoda) Iwu, Nnaemeka Wilfred (2010)
Transcriptional Upregulation of DNA Damage Response Genes in Bank Voles (Myodes glareolus) Inhabiting the Chernobyl Exclusion Zone Jernfors, Toni; Kesäniemi, Jenni; Lavrinienko, Anton; Mappes, Tapio; Milinevsky, Gennadi; Møller, Anders P.; Mousseau, Timothy A.; Tukalenko, Eugene; Watts, Phillip C. (Frontiers Media, 2018)Exposure to ionizing radiation (IR) from radionuclides released into the environment can damage DNA. An expected response to exposure to environmental radionuclides, therefore, is initiation of DNA damage response (DDR) ...
Lisämateriaali artikkeliin "Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent". Kivisaari, Kati; Watts, Phillip; Lavrinienko, Anton; Mappes, Tapio; Kesäniemi, Jenni; Jernfors, Toni; Kiljunen, MikkoElectronic material for Kesäniemi J, Jernfors T, Lavrinienko A, Kivisaari K, Kiljunen M, Mappes T & Watts PC. 2019. Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a ...