N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
Nyandoro, S. S., Ndanu, J., Munissi, J. J. E., Gruhonjic, A., Fitzpatrick, P. A., Landberg, G., Lu, Y., Wang, B., Pan, F., Rissanen, K., & Erdélyi, M. (2015). N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. Journal of Natural Products, 78(8), 2045-2050. https://doi.org/10.1021/acs.jnatprod.5b00356
Julkaistu sarjassa
Journal of Natural ProductsTekijät
Lu, Yu |
Päivämäärä
2015Tekijänoikeudet
© the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine
E (2), toussaintine F (6), and toussaintine G (7), were isolated from
the methanol extract of the leaves of Toussaintia orientalis using column
chromatography and HPLC. The configurations of E-toussaintine E (1) and
toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction
data from racemic crystals. Both the crude methanol extract and the isolated
constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the
H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic
(ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast
cancer cell line.
Julkaisija
American Society of PharmacognosyISSN Hae Julkaisufoorumista
0163-3864Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/24860585
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