Näytä suppeat kuvailutiedot

dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorNdanu, Joseph
dc.contributor.authorMunissi, Joan J. E.
dc.contributor.authorGruhonjic, Amra
dc.contributor.authorFitzpatrick, Paul A.
dc.contributor.authorLandberg, Göran
dc.contributor.authorLu, Yu
dc.contributor.authorWang, Bin
dc.contributor.authorPan, Fangfang
dc.contributor.authorRissanen, Kari
dc.contributor.authorErdélyi, Máté
dc.date.accessioned2016-07-01T06:20:30Z
dc.date.available2016-07-01T06:20:30Z
dc.date.issued2015
dc.identifier.citationNyandoro, S. S., Ndanu, J., Munissi, J. J. E., Gruhonjic, A., Fitzpatrick, P. A., Landberg, G., Lu, Y., Wang, B., Pan, F., Rissanen, K., & Erdélyi, M. (2015). N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. <i>Journal of Natural Products</i>, <i>78</i>(8), 2045-2050. <a href="https://doi.org/10.1021/acs.jnatprod.5b00356" target="_blank">https://doi.org/10.1021/acs.jnatprod.5b00356</a>
dc.identifier.otherCONVID_24860585
dc.identifier.otherTUTKAID_66988
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/50672
dc.description.abstractSeven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line.
dc.language.isoeng
dc.publisherAmerican Society of Pharmacognosy
dc.relation.ispartofseriesJournal of Natural Products
dc.subject.othertoussaintia orientalis
dc.subject.othern-cinnamoyltetraketide
dc.titleN-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201606303417
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemiafi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineOrganic Chemistryen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-06-30T12:15:34Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2045-2050
dc.relation.issn0163-3864
dc.relation.numberinseries8
dc.relation.volume78
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
dc.rights.accesslevelopenAccessfi
dc.subject.ysokemia
jyx.subject.urihttp://www.yso.fi/onto/yso/p1801
dc.rights.urlhttp://pubs.acs.org/page/policy/authorchoice_termsofuse.html
dc.relation.doi10.1021/acs.jnatprod.5b00356
dc.type.okmA1


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Näytä suppeat kuvailutiedot

Ellei muuten mainita, aineiston lisenssi on © the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.