N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
dc.contributor.author | Nyandoro, Stephen S. | |
dc.contributor.author | Ndanu, Joseph | |
dc.contributor.author | Munissi, Joan J. E. | |
dc.contributor.author | Gruhonjic, Amra | |
dc.contributor.author | Fitzpatrick, Paul A. | |
dc.contributor.author | Landberg, Göran | |
dc.contributor.author | Lu, Yu | |
dc.contributor.author | Wang, Bin | |
dc.contributor.author | Pan, Fangfang | |
dc.contributor.author | Rissanen, Kari | |
dc.contributor.author | Erdélyi, Máté | |
dc.date.accessioned | 2016-07-01T06:20:30Z | |
dc.date.available | 2016-07-01T06:20:30Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Nyandoro, S. S., Ndanu, J., Munissi, J. J. E., Gruhonjic, A., Fitzpatrick, P. A., Landberg, G., Lu, Y., Wang, B., Pan, F., Rissanen, K., & Erdélyi, M. (2015). N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. <i>Journal of Natural Products</i>, <i>78</i>(8), 2045-2050. <a href="https://doi.org/10.1021/acs.jnatprod.5b00356" target="_blank">https://doi.org/10.1021/acs.jnatprod.5b00356</a> | |
dc.identifier.other | CONVID_24860585 | |
dc.identifier.other | TUTKAID_66988 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/50672 | |
dc.description.abstract | Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line. | |
dc.language.iso | eng | |
dc.publisher | American Society of Pharmacognosy | |
dc.relation.ispartofseries | Journal of Natural Products | |
dc.subject.other | toussaintia orientalis | |
dc.subject.other | n-cinnamoyltetraketide | |
dc.title | N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201606303417 | |
dc.contributor.laitos | Kemian laitos | fi |
dc.contributor.laitos | Department of Chemistry | en |
dc.contributor.oppiaine | Orgaaninen kemia | fi |
dc.contributor.oppiaine | Nanoscience Center | fi |
dc.contributor.oppiaine | Organic Chemistry | en |
dc.contributor.oppiaine | Nanoscience Center | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2016-06-30T12:15:34Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 2045-2050 | |
dc.relation.issn | 0163-3864 | |
dc.relation.numberinseries | 8 | |
dc.relation.volume | 78 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | kemia | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p1801 | |
dc.rights.url | http://pubs.acs.org/page/policy/authorchoice_termsofuse.html | |
dc.relation.doi | 10.1021/acs.jnatprod.5b00356 | |
dc.type.okm | A1 |
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Ellei muuten mainita, aineiston lisenssi on © the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.