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dc.contributor.authorSillanpää, Elina
dc.contributor.authorTörmäkangas, Timo
dc.contributor.authorRantanen, Taina
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorSipilä, Sarianna
dc.date.accessioned2016-03-16T07:57:46Z
dc.date.available2017-03-04T22:45:06Z
dc.date.issued2016
dc.identifier.citationSillanpää, E., Törmäkangas, T., Rantanen, T., Kaprio, J., & Sipilä, S. (2016). Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?. <em>AGE</em>, 38 (2), 34. <a href="http://dx.doi.org/10.1007/s11357-016-9898-x">doi:10.1007/s11357-016-9898-x</a>
dc.identifier.otherTUTKAID_69436
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/49065
dc.description.abstractBackground: Leucocyte telomere length (LTL) is known to be associated with mortality, but its association with age-related decline in physical functioning and the development of disability is less clear. This study examined the associations between LTL and physical functioning, and investigated whether LTL predicts level of physical functioning over an 11- year follow-up. Methods: Older mono- (MZ) and dizygotic (DZ) twin sisters (n=386) participated in the study. Relative LTL was measured by qPCR at baseline. Physical functioning was measured by 6-min walking distance and level of physical activity (PA). Walking distance was measured at baseline and at 3-year follow-up. PA was assessed by questionnaire at baseline and at 3- and 11-year follow-ups. The baseline analysis was performed with path models, adjusted with age and within-pair dependence of twin pairs. The longitudinal analysis was performed with a repeated measures linear model adjusted for age and longitudinal within-pair dependence. A non-random missing data analysis was utilized. Results: At baseline, in all individuals LTL was associated with PA (est. 0.14 SE 0.06 p=0.011), but not with walking distance. Over the follow-up, a borderline significant association was observed between LTL and walking distance (est. 0.14 SE 0.07 p=0.060) and a significant association between LTL and PA (est. 0.19 SE 0.06 p=0.001). Conclusions: The results suggest that LTL is associated with PA and may, therefore, serve as a biomarker predicting the development of disability. Longitudinal associations between LTL and PA were observed only when nonrandom data missingness was taken into account in the analysis.
dc.language.isoeng
dc.publisherSpringer Netherlands; American Aging Association
dc.relation.ispartofseriesAGE
dc.subject.othertelomere
dc.subject.othertwin study
dc.subject.otherphysical functioning
dc.subject.othersix-minute walking test
dc.subject.otherphysical activity
dc.subject.otherbiological aging
dc.subject.othermissing data not at random
dc.titleDoes telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201603141840
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-03-14T13:15:04Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn2452-0756
dc.relation.volume38
dc.type.versionacceptedVersion
dc.rights.copyright© American Aging Association 2016. This is a final draft version of an article whose final and definitive form has been published by Springer. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1007/s11357-016-9898-x


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