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dc.contributor.authorNokia, Miriam
dc.contributor.authorPenttonen, Markku
dc.contributor.authorKorhonen, Tapani
dc.contributor.authorWikgren, Jan
dc.date.accessioned2015-12-16T09:38:36Z
dc.date.available2015-12-16T09:38:36Z
dc.date.issued2008
dc.identifier.citationNokia, M., Penttonen, M., Korhonen, T., & Wikgren, J. (2008). Hippocampal theta (3-8 Hz) activity during classical eyeblink conditioning in rabbits. <em>Neurobiology of Learning and Memory</em>, 90 (1), 62-70. <a href="http://dx.doi.org/10.1016/j.nlm.2008.01.005">doi:10.1016/j.nlm.2008.01.005</a>
dc.identifier.otherTUTKAID_30947
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/48132
dc.description.abstractIn 1978, Berry and Thompson showed that the amount of theta (3–8 Hz) activity in the spontaneous hippocampal EEG predicted learning rate in subsequent eyeblink conditioning in rabbits. More recently, the absence of theta activity during the training trial has been shown to have a detrimental effect on learning rate. Here, we aimed to further explore the relationship between theta activity and classical eyeblink conditioning by determining how the relative power of hippocampal theta activity [theta/(theta + delta) ratio] changes during both unpaired control and paired training phases. We found that animals with a higher hippocampal theta ratio immediately before conditioning learned faster and also that in these animals the theta ratio was higher throughout both experimental phases. In fact, while the hippocampal theta ratio remained stable in the fast learners as a function of training, it decreased in the slow learners already during unpaired training. In addition, the presence of hippocampal theta activity enhanced the hippocampal model of the conditioned response (CR) and seemed to be beneficial for CR performance in terms of peak latency during conditioning, but did not have any effect when the animals showed asymptotic learning. Together with earlier findings, these results imply that the behavioral state in which hippocampal theta activity is absent is detrimental for learning, and that the behavioral state in which hippocampal theta activity dominates is beneficial for learning, at least before a well-learned state is achieved.
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesNeurobiology of Learning and Memory
dc.subject.otherhippokampus
dc.subject.othereeg
dc.subject.otherklassinen ehdollistaminen
dc.subject.otherdelay ehdollistaminen
dc.subject.otherHippocampus
dc.subject.otherEEG
dc.subject.otherClassical conditioning
dc.subject.otherDelay conditioning
dc.titleHippocampal theta (3-8 Hz) activity during classical eyeblink conditioning in rabbits
dc.typearticle
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201512154039
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2015-12-15T13:15:07Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange62-70
dc.relation.issn1074-7427
dc.relation.volume90
dc.type.versionacceptedVersion
dc.rights.copyright© 2008 Elsevier Inc. This is a final draft version of an article whose final and definitive form has been published by Elsevier. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccess
dc.relation.doi10.1016/j.nlm.2008.01.005


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