Hippocampal theta (3-8 Hz) activity during classical eyeblink conditioning in rabbits
Nokia, M., Penttonen, M., Korhonen, T., & Wikgren, J. (2008). Hippocampal theta (3-8 Hz) activity during classical eyeblink conditioning in rabbits. Neurobiology of Learning and Memory, 90(1), 62-70. https://doi.org/10.1016/j.nlm.2008.01.005
Published inNeurobiology of Learning and Memory
DisciplinePsykologiaMonitieteinen aivotutkimuskeskusPsychologyCentre for Interdisciplinary Brain Research
© 2008 Elsevier Inc. This is a final draft version of an article whose final and definitive form has been published by Elsevier. Published in this repository with the kind permission of the publisher.
In 1978, Berry and Thompson showed that the amount of theta (3–8 Hz) activity in the spontaneous hippocampal EEG predicted learning rate in subsequent eyeblink conditioning in rabbits. More recently, the absence of theta activity during the training trial has been shown to have a detrimental effect on learning rate. Here, we aimed to further explore the relationship between theta activity and classical eyeblink conditioning by determining how the relative power of hippocampal theta activity [theta/(theta + delta) ratio] changes during both unpaired control and paired training phases. We found that animals with a higher hippocampal theta ratio immediately before conditioning learned faster and also that in these animals the theta ratio was higher throughout both experimental phases. In fact, while the hippocampal theta ratio remained stable in the fast learners as a function of training, it decreased in the slow learners already during unpaired training. In addition, the presence of hippocampal theta activity enhanced the hippocampal model of the conditioned response (CR) and seemed to be beneficial for CR performance in terms of peak latency during conditioning, but did not have any effect when the animals showed asymptotic learning. Together with earlier findings, these results imply that the behavioral state in which hippocampal theta activity is absent is detrimental for learning, and that the behavioral state in which hippocampal theta activity dominates is beneficial for learning, at least before a well-learned state is achieved. ...
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Hippocampal theta activity is selectively associated with contingency detection but not discrimination in rabbit discrimination-reversal eyeblink conditioning Nokia, Miriam; Wikgren, Jan (Wiley, 2010)The relative power of the hippocampal theta-band (∼6 Hz) activity (theta ratio) is thought to reflect a distinct neural state and has been shown to affect learning rate in classical eyeblink conditioning in rabbits. We ...
Nokia, Miriam; Penttonen, Markku; Korhonen, Tapani; Wikgren, Jan (APA, 2009)The authors examined the relationship between hippocampal theta activity and trace eyeblink conditioning. Hippocampal electrophysiological local field potentials were recorded before, during, and after conditioning or ...
Nokia, Miriam (University of Jyväskylä, 2009)
Raussi, Pekka (2014)
Hippocampal ripple-contingent training accelerates trace eyeblink conditioning and retards extinction in rabbits Nokia, Miriam; Penttonen, Markku; Wikgren, Jan (Society for Neuroscience, 2010)There are at least two distinct oscillatory states of the hippocampus that are related to distinct behavioral patterns. Theta (4–12 Hz) oscillation has been suggested to indicate selective attention during which the animal ...