dc.contributor.author | Kangas, Reeta | |
dc.contributor.author | Laakkonen, Eija | |
dc.contributor.author | Kovanen, Vuokko | |
dc.date.accessioned | 2015-12-04T09:11:55Z | |
dc.date.available | 2015-12-04T09:11:55Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Kangas, R., Laakkonen, E., & Kovanen, V. (2015). Aging and systemic hormonal status affects the circulating miR-21, miR-146a and FasL levels. <i>RNA and Disease</i>, <i>2</i>(2), Article e552. <a href="https://doi.org/10.14800/rd.552" target="_blank">https://doi.org/10.14800/rd.552</a> | |
dc.identifier.other | CONVID_25329548 | |
dc.identifier.other | TUTKAID_67978 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/47985 | |
dc.description.abstract | MicroRNAs are small molecules, found in all cell types and body fluids, which most commonly affect negatively
to gene expressions by translational repression. Their role in various physiological conditions and diseases has
been emphasized during the last twenty years. In our recent studies with postmenopausal monozygotic twin
sisters (n=11), we have investigated how different systemic hormonal status affects the levels of specific
circulating microRNAs and other molecules related to inflammation and apoptosis, both processes associated
with aging. Our results have shown that the systemic levels of miR-21, miR-146a and Fas ligand are lower within
the postmenopausal women who are using estrogen-based hormonal replacement (HRT), compared to their
non-using co-twins (p=0.018, p=0.039, p=0.021, respectively). To get further knowledge about the aging effect, we
also measured the same markers from the premenopausal control women (n=8), with natural hormonal status,
and found out that the inflammatory profile was healthier among the young women and that the serum miR-21
profile was more similar with the HRT users than non-users, and miR-146 and FasL profile more similar to
non-users. These findings demonstrate that HRT has effects on the circulating inflammation related regulatory
molecules. Whether we can state that the effects are clearly positive or negative, needs further investigations and
understanding of the regulatory system. | |
dc.language.iso | eng | |
dc.publisher | Smart Science & Technology LLC | |
dc.relation.ispartofseries | RNA and Disease | |
dc.subject.other | agings | |
dc.subject.other | miR-21 | |
dc.subject.other | miR-146 | |
dc.subject.other | FasL | |
dc.title | Aging and systemic hormonal status affects the circulating miR-21, miR-146a and FasL levels | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201512033903 | |
dc.contributor.laitos | Terveystieteiden laitos | fi |
dc.contributor.laitos | Department of Health Sciences | en |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.type.uri | http://purl.org/eprint/type/JournalItem | |
dc.date.updated | 2015-12-03T10:15:02Z | |
dc.type.coar | journal article | |
dc.description.reviewstatus | nonPeerReviewed | |
dc.relation.issn | 2375-2467 | |
dc.relation.numberinseries | 2 | |
dc.relation.volume | 2 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2015 Kangas, Pöllänen & Kovanen. Published by Smart Science & Technology LLC under the Creative Commons Attribution License. | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | hormonit | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p2589 | |
dc.rights.url | http://creativecommons.org/licenses/by/3.0/ | |
dc.relation.doi | 10.14800/rd.552 | |