Aging and systemic hormonal status affects the circulating miR-21, miR-146a and FasL levels
Kangas, R., Laakkonen, E., & Kovanen, V. (2015). Aging and systemic hormonal status affects the circulating miR-21, miR-146a and FasL levels. RNA and Disease, 2(2), Article e552. https://doi.org/10.14800/rd.552
Published inRNA and Disease
© 2015 Kangas, Pöllänen & Kovanen. Published by Smart Science & Technology LLC under the Creative Commons Attribution License.
MicroRNAs are small molecules, found in all cell types and body fluids, which most commonly affect negatively to gene expressions by translational repression. Their role in various physiological conditions and diseases has been emphasized during the last twenty years. In our recent studies with postmenopausal monozygotic twin sisters (n=11), we have investigated how different systemic hormonal status affects the levels of specific circulating microRNAs and other molecules related to inflammation and apoptosis, both processes associated with aging. Our results have shown that the systemic levels of miR-21, miR-146a and Fas ligand are lower within the postmenopausal women who are using estrogen-based hormonal replacement (HRT), compared to their non-using co-twins (p=0.018, p=0.039, p=0.021, respectively). To get further knowledge about the aging effect, we also measured the same markers from the premenopausal control women (n=8), with natural hormonal status, and found out that the inflammatory profile was healthier among the young women and that the serum miR-21 profile was more similar with the HRT users than non-users, and miR-146 and FasL profile more similar to non-users. These findings demonstrate that HRT has effects on the circulating inflammation related regulatory molecules. Whether we can state that the effects are clearly positive or negative, needs further investigations and understanding of the regulatory system. ...
PublisherSmart Science & Technology LLC
ISSN Search the Publication Forum2375-2467
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Except where otherwise noted, this item's license is described as © 2015 Kangas, Pöllänen & Kovanen. Published by Smart Science & Technology LLC under the Creative Commons Attribution License.
Showing items with similar title or keywords.
Menstrual cycle and hormonal contraception : associations between hormones, physical performance, and menstrual cycle -related symptoms Pesonen, Emilia (2020)Introduction. It has been reported that 42 % of exercising women feel that the menstrual cycle negatively affects their performance (Bruinvels et al. 2016). However, athletes must train and compete in each phase of the ...
Neuromuscular, hormonal and molecular responses to heavy resistance training in strength trained men : with special reference to various resistance exercise protocols, serum hormones and gene expression of androgen receptor and insulin-like growth factor-I Ahtiainen, Juha (University of Jyväskylä, 2006)The present study was designed to obtain more information on mechanisms leading to muscle hypertrophy by determination of the effects of different heavy resistance exercise protocols on acute and chronic neuromuscular and ...
Influence of Menstrual Cycle or Hormonal Contraceptive Phase on Energy Intake and Metabolic Hormones : A Pilot Study Ihalainen, Johanna K.; Löfberg, Ida; Kotkajuuri, Anna; Kyröläinen, Heikki; Hackney, Anthony C.; Taipale-Mikkonen, Ritva S. (MDPI AG, 2021)Sex hormones are suggested to influence energy intake (EI) and metabolic hormones. This study investigated the influence of menstrual cycle (MC) and hormonal contraceptive (HC) cycle phases on EI, energy availability (EA), ...
Basal Endogenous Steroid Hormones, Sex Hormone-Binding Globulin, Physical Fitness, and Health Risk Factors in Young Adult Men Gagnon, Sheila S.; Nindl, Bradley C.; Vaara, Jani; Santtila, Matti; Häkkinen, Keijo; Kyröläinen, Heikki (Frontiers Research Foundation, 2018)Purpose: Few large-scale population-based studies have adequately examined the relationships between steroid hormones, health status and physical fitness. The purpose of the study was to describe the relationship of serum ...
Circulating miR-21, miR-146a and Fas ligand respond to postmenopausal estrogen-based hormone replacement therapy : A study with monozygotic twin pairs Kangas, Reeta; Pöllänen, Eija; Rippo, Maria Rita; Lanzarini, Catia; Prattichizzo, Francesco; Niskala, Paula; Jylhävä, Juulia; Sipilä, Sarianna; Kaprio, Jaakko; Procopio, Antonio Domenico; Capri, Miriam; Franceschi, Claudio; Olivieri, Fabiola; Kovanen, Vuokko (Elsevier Ireland Ltd., 2014)Biological aging is associated with physiological deteriorations and its’ remodeling, which are partly due to changes in the hormonal profile. MicroRNAs are known to post-transcriptionally regulate various cellular processes ...