Phase matters: responding to and learning about peripheral stimuli depends on hippocampal θ phase at stimulus onset
Nokia, M., Waselius, T., Mikkonen, J., Wikgren, J., & Penttonen, M. (2015). Phase matters: responding to and learning about peripheral stimuli depends on hippocampal θ phase at stimulus onset. Learning and Memory, 22(6), 307-317. https://doi.org/10.1101/lm.038166.115
Julkaistu sarjassa
Learning and MemoryPäivämäärä
2015Oppiaine
PsykologiaMonitieteinen aivotutkimuskeskusHyvinvoinnin tutkimuksen yhteisöPsychologyCentre for Interdisciplinary Brain ResearchSchool of WellbeingTekijänoikeudet
© 2015 Nokia et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Learning & Memory, is available under a Creative Commons License.
Hippocampal θ (3–12 Hz) oscillations are implicated in learning and memory, but their functional role remains unclear. We studied the effect of the phase of local θ oscillation on hippocampal responses to a neutral conditioned stimulus (CS) and subsequent learning of classical trace eyeblink conditioning in adult rabbits. High-amplitude, regular hippocampal θ-band responses (that predict good learning) were elicited by the CS when it was timed to commence at the fissure θ trough (Trough group). Regardless, learning in this group was not enhanced compared with a yoked control group, possibly due to a ceiling effect. However, when the CS was consistently presented to the peak of θ (Peak group), hippocampal θ-band responding was less organized and learning was retarded. In well-trained animals, the hippocampal θ phase at CS onset no longer affected performance of the learned response, suggesting a time-limited role for hippocampal processing in learning. To our knowledge, this is the first study to demonstrate that timing a peripheral stimulus to a specific phase of the hippocampal θ cycle produces robust effects on the synchronization of neural responses and affects learning at the behavioral level. Our results support the notion that the phase of spontaneous hippocampal θ oscillation is a means of regulating the processing of information in the brain to a behaviorally relevant degree.
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Julkaisija
Cold Spring Harbor Laboratory PressISSN Hae Julkaisufoorumista
1072-0502Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/24711417
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The work was supported by the Academy of Finland (grant no. 139767 to M.P. and grant no. 275954 to M.S.N.).Lisenssi
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