dc.contributor.author | Nokia, Miriam | |
dc.contributor.author | Waselius, Tomi | |
dc.contributor.author | Mikkonen, Jarno | |
dc.contributor.author | Wikgren, Jan | |
dc.contributor.author | Penttonen, Markku | |
dc.date.accessioned | 2015-05-21T08:57:35Z | |
dc.date.available | 2015-05-21T08:57:35Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Nokia, M., Waselius, T., Mikkonen, J., Wikgren, J., & Penttonen, M. (2015). Phase matters: responding to and learning about peripheral stimuli depends on hippocampal θ phase at stimulus onset. <i>Learning and Memory</i>, <i>22</i>(6), 307-317. <a href="https://doi.org/10.1101/lm.038166.115" target="_blank">https://doi.org/10.1101/lm.038166.115</a> | |
dc.identifier.other | CONVID_24711417 | |
dc.identifier.other | TUTKAID_66166 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/45973 | |
dc.description.abstract | Hippocampal θ (3–12 Hz) oscillations are implicated in learning and memory, but their functional role remains unclear. We studied the effect of the phase of local θ oscillation on hippocampal responses to a neutral conditioned stimulus (CS) and subsequent learning of classical trace eyeblink conditioning in adult rabbits. High-amplitude, regular hippocampal θ-band responses (that predict good learning) were elicited by the CS when it was timed to commence at the fissure θ trough (Trough group). Regardless, learning in this group was not enhanced compared with a yoked control group, possibly due to a ceiling effect. However, when the CS was consistently presented to the peak of θ (Peak group), hippocampal θ-band responding was less organized and learning was retarded. In well-trained animals, the hippocampal θ phase at CS onset no longer affected performance of the learned response, suggesting a time-limited role for hippocampal processing in learning. To our knowledge, this is the first study to demonstrate that timing a peripheral stimulus to a specific phase of the hippocampal θ cycle produces robust effects on the synchronization of neural responses and affects learning at the behavioral level. Our results support the notion that the phase of spontaneous hippocampal θ oscillation is a means of regulating the processing of information in the brain to a behaviorally relevant degree. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Cold Spring Harbor Laboratory Press | |
dc.relation.ispartofseries | Learning and Memory | |
dc.rights | CC BY-NC 4.0 | |
dc.subject.other | memory | |
dc.subject.other | hippocampal | |
dc.title | Phase matters: responding to and learning about peripheral stimuli depends on hippocampal θ phase at stimulus onset | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201505211929 | |
dc.contributor.laitos | Psykologian laitos | fi |
dc.contributor.laitos | Department of Psychology | en |
dc.contributor.oppiaine | Psykologia | fi |
dc.contributor.oppiaine | Monitieteinen aivotutkimuskeskus | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Psychology | en |
dc.contributor.oppiaine | Centre for Interdisciplinary Brain Research | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2015-05-21T06:15:02Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 307-317 | |
dc.relation.issn | 1072-0502 | |
dc.relation.numberinseries | 6 | |
dc.relation.volume | 22 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2015 Nokia et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Learning & Memory, is available under a Creative Commons License. | |
dc.rights.accesslevel | openAccess | |
dc.relation.grantnumber | 275954 | |
dc.subject.yso | oppiminen | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p2945 | |
dc.rights.url | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.relation.doi | 10.1101/lm.038166.115 | |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Suomen Akatemia | fi |
jyx.fundingprogram | Academy Research Fellow, AoF | en |
jyx.fundingprogram | Akatemiatutkija, SA | fi |
jyx.fundinginformation | The work was supported by the Academy of Finland (grant no. 139767 to M.P. and grant no. 275954 to M.S.N.). | |
dc.type.okm | A1 | |