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dc.contributor.authorNokia, Miriam
dc.contributor.authorWaselius, Tomi
dc.contributor.authorMikkonen, Jarno
dc.contributor.authorWikgren, Jan
dc.contributor.authorPenttonen, Markku
dc.date.accessioned2015-05-21T08:57:35Z
dc.date.available2015-05-21T08:57:35Z
dc.date.issued2015
dc.identifier.citationNokia, M., Waselius, T., Mikkonen, J., Wikgren, J., & Penttonen, M. (2015). Phase matters: responding to and learning about peripheral stimuli depends on hippocampal θ phase at stimulus onset. <i>Learning and Memory</i>, <i>22</i>(6), 307-317. <a href="https://doi.org/10.1101/lm.038166.115" target="_blank">https://doi.org/10.1101/lm.038166.115</a>
dc.identifier.otherCONVID_24711417
dc.identifier.otherTUTKAID_66166
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/45973
dc.description.abstractHippocampal θ (3–12 Hz) oscillations are implicated in learning and memory, but their functional role remains unclear. We studied the effect of the phase of local θ oscillation on hippocampal responses to a neutral conditioned stimulus (CS) and subsequent learning of classical trace eyeblink conditioning in adult rabbits. High-amplitude, regular hippocampal θ-band responses (that predict good learning) were elicited by the CS when it was timed to commence at the fissure θ trough (Trough group). Regardless, learning in this group was not enhanced compared with a yoked control group, possibly due to a ceiling effect. However, when the CS was consistently presented to the peak of θ (Peak group), hippocampal θ-band responding was less organized and learning was retarded. In well-trained animals, the hippocampal θ phase at CS onset no longer affected performance of the learned response, suggesting a time-limited role for hippocampal processing in learning. To our knowledge, this is the first study to demonstrate that timing a peripheral stimulus to a specific phase of the hippocampal θ cycle produces robust effects on the synchronization of neural responses and affects learning at the behavioral level. Our results support the notion that the phase of spontaneous hippocampal θ oscillation is a means of regulating the processing of information in the brain to a behaviorally relevant degree.en
dc.language.isoeng
dc.publisherCold Spring Harbor Laboratory Press
dc.relation.ispartofseriesLearning and Memory
dc.subject.othermemory
dc.subject.otherhippocampal
dc.titlePhase matters: responding to and learning about peripheral stimuli depends on hippocampal θ phase at stimulus onset
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201505211929
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2015-05-21T06:15:02Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange307-317
dc.relation.issn1072-0502
dc.relation.numberinseries6
dc.relation.volume22
dc.type.versionpublishedVersion
dc.rights.copyright© 2015 Nokia et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Learning & Memory, is available under a Creative Commons License.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber275954
dc.subject.ysooppiminen
jyx.subject.urihttp://www.yso.fi/onto/yso/p2945
dc.rights.urlhttp://creativecommons.org/licenses/by-nc/4.0/
dc.relation.doi10.1101/lm.038166.115
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundinginformationThe work was supported by the Academy of Finland (grant no. 139767 to M.P. and grant no. 275954 to M.S.N.).


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© 2015 Nokia et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Learning & Memory, is available under a Creative Commons License.
Except where otherwise noted, this item's license is described as © 2015 Nokia et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Learning & Memory, is available under a Creative Commons License.