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dc.contributor.authorAlbrecht, Eva
dc.contributor.authorSillanpää, Elina
dc.contributor.authorKarrasch, Stefan
dc.contributor.authorAlves, Alexessander Couto
dc.contributor.authorCodd, Veryan
dc.contributor.authorHovatta, Iiris
dc.contributor.authorBuxton, Jessica L
dc.contributor.authorNelson, Christopher P
dc.contributor.authorBroer, Linda
dc.contributor.authorHägg, Sara
dc.contributor.authorMangino, Massimo
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorSurakka, Ida
dc.contributor.authorFerreira, Manuel AR
dc.contributor.authorAmin, Najaf
dc.contributor.authorOostra, Ben A
dc.contributor.authorBäckmand, Heli M
dc.contributor.authorPeltonen, Markku
dc.contributor.authorSarna, Seppo
dc.contributor.authorRantanen, Taina
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorKorhonen, Tellervo
dc.contributor.authorMadden, Pamela AF
dc.contributor.authorGieger, Christian
dc.contributor.authorJörres, Rudolf A
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorBehr, Jürgen
dc.contributor.authorHuber, Rudolf M
dc.contributor.authorPeters, Annette
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorWichmann, H.Erich
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorBlakemore, Alexandra IF
dc.contributor.authorGeus, Eco JC de
dc.contributor.authorNyholt, Dale R
dc.contributor.authorHenders, Anjali K
dc.contributor.authorPiirilä, Päivi L
dc.contributor.authorRissanen, Aila
dc.contributor.authorMagnusson, Patrik KE
dc.contributor.authorViñuela, Ana
dc.contributor.authorPietiläinen, Kirsi H
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorPedersen, Nancy L
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorSpector, Tim D
dc.contributor.authorDuijn, Cornelia M van
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorSamani, Nilesh J
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorSchulz, Holger
dc.date.accessioned2015-01-19T08:15:04Z
dc.date.available2015-06-05T21:45:07Z
dc.date.issued2014
dc.identifier.citationAlbrecht, E., Sillanpää, E., Karrasch, S., Alves, A., Codd, V., Hovatta, I., . . . Schulz, H. (2014). Telomere length in circulating leukocytes is associated with lung function and disease. <em>European Respiratory Journal</em>, 43 (4), 983-992. <a href="http://dx.doi.org/10.1183/09031936.00046213">doi:10.1183/09031936.00046213</a>
dc.identifier.otherTUTKAID_60390
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/45114
dc.description.abstractSeveral clinical studies suggest the involvement of premature aging processes in COPD. Using an epidemiological approach we studied whether accelerated aging indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the inter-individual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15,846 controls defined according to GLI criteria (or 1,189 COPD cases according to GOLD), 2,834 asthma cases with 28,195 controls, and spirometric parameters (FEV1, FVC and FEV1/FVC) of 12,595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex, and smoking status.We observed negative associations between telomere length and COPD being stronger for COPD defined by GLI than GOLD (β=-0.0982, p=0.001 vs. β=-0.0676, p=0.018) as well as asthma (β=-0.0452, p=0.024), with stronger effects in women compared to men. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07x10-7), FVC (p=2.07x10-5), and their ratio FEV1/FVC (p=5.27x10-3). The effect was somewhat weaker in apparently healthy subjects compared to COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma and that lung function may reflect biological aging primarily due to intrinsic processes which are likely to be aggravated in lung diseases.
dc.language.isoeng
dc.publisherEuropean Respiratory Society
dc.relation.ispartofseriesEuropean Respiratory Journal
dc.subject.otherbiological ageen
dc.subject.otherpremature agingen
dc.subject.otherCOPDen
dc.subject.otherasthmaen
dc.subject.otherspirometryen
dc.subject.otherbiologinen ikäfi
dc.subject.othertelomeerifi
dc.subject.otherspirometriafi
dc.subject.otherkeuhkoahtaumatautifi
dc.subject.otherastmafi
dc.subject.otherennenaikainen vanheneminenfi
dc.titleTelomere length in circulating leukocytes is associated with lung function and disease
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201412313592
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2014-12-31T04:30:03Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange983-992
dc.relation.issn1399-3003
dc.relation.numberinseries4
dc.relation.volume43
dc.type.versionacceptedVersion
dc.rights.copyright© European Respiratory Society 2014. This is an author's final draft version of an article whose final and definitive form has been published by ERS. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1183/09031936.00046213


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