dc.contributor.author | Kainulainen, Heikki | |
dc.contributor.author | Papaioannou, Konstantinos G. | |
dc.contributor.author | Silvennoinen, Mika | |
dc.contributor.author | Autio, Reija | |
dc.contributor.author | Saarela, Janne | |
dc.contributor.author | Oliveira, Bernardo M. | |
dc.contributor.author | Nyqvist, Miro | |
dc.contributor.author | Pasternack, Arja | |
dc.contributor.author | Hoen, Peter A.C. ’t | |
dc.contributor.author | Kujala, Urho | |
dc.contributor.author | Ritvos, Olli | |
dc.contributor.author | Hulmi, Juha | |
dc.date.accessioned | 2014-12-17T07:48:30Z | |
dc.date.available | 2014-12-17T07:48:30Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Kainulainen, H., Papaioannou, K. G., Silvennoinen, M., Autio, R., Saarela, J., Oliveira, B. M., Nyqvist, M., Pasternack, A., Hoen, P. A. ’., Kujala, U., Ritvos, O., & Hulmi, J. (2015). Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. <i>Molecular and cellular endocrinology</i>, <i>399</i>(January), 131-142. <a href="https://doi.org/10.1016/j.mce.2014.10.001" target="_blank">https://doi.org/10.1016/j.mce.2014.10.001</a> | |
dc.identifier.other | CONVID_23930514 | |
dc.identifier.other | TUTKAID_63359 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/44922 | |
dc.description.abstract | Duchenne Muscular Dystrophy is characterized by muscle wasting and decreased aerobic
metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined
counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble
activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in
combination for seven weeks in dystrophic mdx mice. Expression microarray analysis revealed
decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice.
This was not due to reduced home-cage physical activity, and was further downregulated upon
sActRIIB-Fc treatment in enlarged muscles. However, exercise activated pathways of aerobic
metabolism and counteracted the negative effects of sActRIIB-Fc. Exercise and sActRIIB-Fc
synergistically increased expression of major urinary protein, but exercise blocked sActRIIB-Fc
induced phosphorylation of STAT5 in gastrocnemius muscle. In conclusion, exercise alone or in
combination with myostatin/activin blocking corrects aerobic gene expression profiles of dystrophic
muscle towards healthy wild type mice profiles. | fi |
dc.language.iso | eng | |
dc.publisher | Elsevier Ireland Ltd | |
dc.relation.ispartofseries | Molecular and cellular endocrinology | |
dc.subject.other | physical activity | |
dc.subject.other | muscular dystrophy | |
dc.subject.other | muscle hypertrophy | |
dc.subject.other | mRNA profiling | |
dc.subject.other | oxidative metabolism | |
dc.title | Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201410243086 | |
dc.contributor.laitos | Liikuntabiologian laitos | fi |
dc.contributor.laitos | Terveystieteiden laitos | fi |
dc.contributor.laitos | Department of Biology of Physical Activity | en |
dc.contributor.laitos | Department of Health Sciences | en |
dc.contributor.oppiaine | Liikuntafysiologia | fi |
dc.contributor.oppiaine | Fysioterapia | fi |
dc.contributor.oppiaine | Liikuntalääketiede | fi |
dc.contributor.oppiaine | Exercise Physiology | en |
dc.contributor.oppiaine | Physiotherapy | en |
dc.contributor.oppiaine | Sports and Exercise Medicine | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2014-10-24T03:30:03Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 131–142 | |
dc.relation.issn | 0303-7207 | |
dc.relation.numberinseries | January | |
dc.relation.volume | 399 | |
dc.type.version | acceptedVersion | |
dc.rights.copyright | © Elsevier Ltd. This is a final draft version of an article whose final and definitive form has been published by Elsevier. | |
dc.rights.accesslevel | openAccess | fi |
dc.relation.doi | 10.1016/j.mce.2014.10.001 | |
dc.type.okm | A1 | |