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dc.contributor.authorKainulainen, Heikki
dc.contributor.authorPapaioannou, Konstantinos G.
dc.contributor.authorSilvennoinen, Mika
dc.contributor.authorAutio, Reija
dc.contributor.authorSaarela, Janne
dc.contributor.authorOliveira, Bernardo M.
dc.contributor.authorNyqvist, Miro
dc.contributor.authorPasternack, Arja
dc.contributor.authorHoen, Peter A.C. ’t
dc.contributor.authorKujala, Urho
dc.contributor.authorRitvos, Olli
dc.contributor.authorHulmi, Juha
dc.date.accessioned2014-12-17T07:48:30Z
dc.date.available2014-12-17T07:48:30Z
dc.date.issued2015
dc.identifier.citationKainulainen, H., Papaioannou, K. G., Silvennoinen, M., Autio, R., Saarela, J., Oliveira, B. M., Nyqvist, M., Pasternack, A., Hoen, P. A. ’., Kujala, U., Ritvos, O., & Hulmi, J. (2015). Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. <i>Molecular and cellular endocrinology</i>, <i>399</i>(January), 131–142. <a href="https://doi.org/10.1016/j.mce.2014.10.001" target="_blank">https://doi.org/10.1016/j.mce.2014.10.001</a>
dc.identifier.otherCONVID_23930514
dc.identifier.otherTUTKAID_63359
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/44922
dc.description.abstractDuchenne Muscular Dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for seven weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However, exercise activated pathways of aerobic metabolism and counteracted the negative effects of sActRIIB-Fc. Exercise and sActRIIB-Fc synergistically increased expression of major urinary protein, but exercise blocked sActRIIB-Fc induced phosphorylation of STAT5 in gastrocnemius muscle. In conclusion, exercise alone or in combination with myostatin/activin blocking corrects aerobic gene expression profiles of dystrophic muscle towards healthy wild type mice profiles.fi
dc.language.isoeng
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofseriesMolecular and cellular endocrinology
dc.subject.otherphysical activity
dc.subject.othermuscular dystrophy
dc.subject.othermuscle hypertrophy
dc.subject.othermRNA profiling
dc.subject.otheroxidative metabolism
dc.titleMyostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201410243086
dc.contributor.laitosLiikuntabiologian laitosfi
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Biology of Physical Activityen
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineFysioterapiafi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiainePhysiotherapyen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2014-10-24T03:30:03Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange131–142
dc.relation.issn0303-7207
dc.relation.numberinseriesJanuary
dc.relation.volume399
dc.type.versionacceptedVersion
dc.rights.copyright© Elsevier Ltd. This is a final draft version of an article whose final and definitive form has been published by Elsevier.
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1016/j.mce.2014.10.001


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