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dc.contributor.authorWiklund, Petri
dc.contributor.authorPekkala, Satu
dc.contributor.authorAutio, Reija
dc.contributor.authorMunukka, Eveliina
dc.contributor.authorXu, Leiting
dc.contributor.authorSaltevo, Juha
dc.contributor.authorCheng, Shumei
dc.contributor.authorKujala, Urho
dc.contributor.authorAlen, Markku
dc.contributor.authorCheng, Sulin
dc.date.accessioned2014-08-13T08:43:29Z
dc.date.available2014-08-13T08:43:29Z
dc.date.issued2014
dc.identifier.citationWiklund, P., Pekkala, S., Autio, R., Munukka, E., Xu, L., Saltevo, J., Cheng, S., Kujala, U., Alen, M., & Cheng, S. (2014). Serum metabolic profiles in overweight and obese women with and without metabolic syndrome. <i>Diabetology & Metabolic Syndrome</i>, <i>6</i>(40). <a href="https://doi.org/10.1186/1758-5996-6-40" target="_blank">https://doi.org/10.1186/1758-5996-6-40</a>
dc.identifier.otherCONVID_23676112
dc.identifier.otherTUTKAID_61860
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/43999
dc.description.abstractObjective: To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body weight and fat mass. Methods: We applied nuclear magnetic resonance spectroscopy-based profiling of fasting serum samples to examine the metabolic differences between 78 previously physically inactive, body weight and fat mass matched overweight/obese premenopausal women with and without MetS. MetS was defined as the presence of at least three of the following five criteria: waist circumference ≥ 88 cm, serum triacylglycerol ≥ 1.7 mmol/L, and high density lipoprotein cholesterol (HDL-C) <1.30 mmol/L, blood pressure ≥ 130/85 mmHg and fasting glucose ≥ 5.6 mmol/L). Principal component analysis was used to reduce the large number of correlated variables to fewer uncorrelated factors. Results: Two metabolic factors were associated with MetS independent of BMI, fat mass, waist circumference and physical activity/fitness. Factor comprising branched-chain amino acids (BCAA) and aromatic amino acids (AAA) and orosomucoid was associated with all clinical risk factors (p < 0.01 for all). Conclusion: Two metabolic factors distinguish overweight/obese women with metabolic syndrome from those who are metabolically healthy independent of body weight, fat mass and physical activity/fitness. In particular, factor comprising BCAA, AAA and orosomucoid seems auspicious biomarker determining metabolic health as it was associated with all clinical risk factors. Further research is needed to determine the public health and clinical significance of these results in terms of screening to identify those at greatest cardio-metabolic risk for whom appropriate intervention strategies should be developed.fi
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.relation.ispartofseriesDiabetology & Metabolic Syndrome
dc.relation.urihttp://www.dmsjournal.com/content/6/1/40
dc.subject.othermetabolomics
dc.titleSerum metabolic profiles in overweight and obese women with and without metabolic syndrome
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201408132347
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2014-08-13T03:32:08Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1758-5996
dc.relation.numberinseries40
dc.relation.volume6
dc.type.versionpublishedVersion
dc.rights.copyright© 2014 Wiklund et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver applies to the data made available in this article, unless otherwise stated.
dc.rights.accesslevelopenAccessfi
dc.subject.ysolihavuus
dc.subject.ysometabolinen oireyhtymä
dc.subject.ysonaiset
jyx.subject.urihttp://www.yso.fi/onto/yso/p823
jyx.subject.urihttp://www.yso.fi/onto/yso/p6238
jyx.subject.urihttp://www.yso.fi/onto/yso/p16991
dc.rights.urlhttp://creativecommons.org/licenses/by/4.0
dc.relation.doi10.1186/1758-5996-6-40
dc.type.okmA1


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© 2014 Wiklund et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as © 2014 Wiklund et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver applies to the data made available in this article, unless otherwise stated.