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dc.contributor.authorLiu, Wu Yi
dc.contributor.authorLu, Da Jiang
dc.contributor.authorDu, Xia Ming
dc.contributor.authorSun, Jian Qin
dc.contributor.authorGe, Jun
dc.contributor.authorWang, Ren Wei
dc.contributor.authorWang, Ru
dc.contributor.authorZou, Jun
dc.contributor.authorXu, Chang
dc.contributor.authorRen, Jie
dc.contributor.authorWen, Xin Fei
dc.contributor.authorLiu, Yang
dc.contributor.authorCheng, Shumei
dc.contributor.authorTan, Xiao
dc.contributor.authorPekkala, Satu
dc.contributor.authorMunukka, Eveliina
dc.contributor.authorWiklund, Petri
dc.contributor.authorChen, Yan Qiu
dc.contributor.authorGu, Qing
dc.contributor.authorXia, Zheng Chang
dc.contributor.authorLiu, Jun Jun
dc.contributor.authorLiu, Wen Bin
dc.contributor.authorChen, Xue Bo
dc.contributor.authorZhang, Yi Min
dc.contributor.authorLi, Rui
dc.contributor.authorBorra, Ronald J H
dc.contributor.authorYao, Jia Xin
dc.contributor.authorChen, Pei Jie
dc.contributor.authorCheng, Sulin
dc.date.accessioned2014-04-04T06:46:20Z
dc.date.available2014-04-04T06:46:20Z
dc.date.issued2014
dc.identifier.citationLiu, W., Lu, D., Du, X., Sun, J., Ge, J., Wang, R., . . . Cheng, S. (2014). Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men: study protocol for the AELC randomized controlled trial. <em>BMC Public Health</em>, 14 (48). <a href="http://dx.doi.org/10.1186/1471-2458-14-48">doi:10.1186/1471-2458-14-48</a> Retrieved from <a href="http://www.biomedcentral.com/1471-2458/14/48">http://www.biomedcentral.com/1471-2458/14/48</a>
dc.identifier.otherTUTKAID_60872
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/43170
dc.description.abstractBackground. Pre-diabetes and non-alcoholic fatty liver disease (NAFLD) are associated with an unhealthy lifestyle and pose extremely high costs to the healthcare system. In this study, we aim to explore whether individualized aerobic exercise (AEx) and low carbohydrate diet (LCh) intervention affect hepatic fat content (HFC) in pre-diabetes via modification of gut microbiota composition and other post-interventional effects. Methods/design. A 6-month randomized intervention with 6-month follow-up is conducted from January 2013 to December 2015. The target sample size for intervention is 200 postmenopausal women and middle-aged men aged 50–65 year-old with pre-diabetes and NAFLD. The qualified subjects are randomized into 4 groups with 50 subjects in each group: 1 = AEx, 2 = LCh, 3 = AEx + LCh, and 4 = control. In addition, two age-matched reference groups (5 = pre-diabetes without NAFLD (n = 50) and 6 = Healthy without pre-diabetes or NAFLD (n = 50)) are included. The exercise program consists of progressive and variable aerobic exercise (intensity of 60 to 75% of initial fitness level, 3–5 times/week and 30–60 min/time). The diet program includes dietary consultation plus supplementation with a special lunch meal (40% of total energy intake/day) which aims to reduce the amount of carbohydrate consumption (30%). The control and reference groups are advised to maintain their habitual habits during the intervention. The primary outcome measures are HFC, serum metabolomics and gut microbiota composition. The secondary outcome measures include body composition and cytokines. In addition, socio-psychological aspects, social support, physical activity and diet will be performed by means of questionnaire and interview. Discussion. Specific individualized exercise and diet intervention in this study offers a more efficient approach for liver fat reduction and diabetes prevention via modification of gut microbiota composition. Besides, the study explores the importance of incorporating fitness assessment and exercise in the management of patients with pre-diabetes and fatty liver disorders. If our program is shown to be effective, it will open new strategies to combat these chronic diseases.
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofseriesBMC Public Health
dc.relation.urihttp://www.biomedcentral.com/1471-2458/14/48
dc.subject.otherliver fat contenten
dc.subject.otherglucose metabolismen
dc.subject.otherlipid metabolismen
dc.subject.othergut microbiotaen
dc.subject.othermetabonomicsen
dc.subject.otherhumanen
dc.subject.otherclinical settingen
dc.titleEffect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men: study protocol for the AELC randomized controlled trial
dc.identifier.urnURN:NBN:fi:jyu-201403151349
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiede
dc.contributor.oppiaineTerveyskasvatus
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.identifier.doi10.1186/1471-2458-14-48
dc.date.updated2014-03-15T04:30:03Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn1471-2458
dc.relation.numberinseries48
dc.relation.volume14
dc.type.versionpublishedVersion
dc.rights.copyright© 2014 Liu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by/2.0/


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© 2014 Liu et al.; licensee BioMed Central Ltd. 


This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as © 2014 Liu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.