Coronary artery calcium and physical performance as determinants of mortality in older age: the AGES-Reykjavik Study
von Bonsdorff, M., Groffen, D., Vidal, J., Rantanen, T., Jonsson, P., Garcia, M., Aspelund, T., Eiriksdottir, G., Siggeirsdottir, Launer, L., Gudnason, V. & Harris, T. (2013). Coronary artery calcium and physical performance as determinants of mortality in older age: the AGES-Reykjavik Study. International Journal of Cardiology, 168 (3), 2049-2099. doi:10.1016/j.ijcard.2013.01.067
Published inInternational Journal of Cardiology
DisciplineGerontologia ja kansanterveys
© Elsevier. This is an author's final draft version of an article whose final and definitive form has bee published by Elsevier.
Background. Coronary artery calcium (CAC) and physical performance have been shown to be associated with mortality, but it is not clear whether one of them modifies the association. We investigated the association between the extent of CAC and physical performance among older individuals and explored these individual and combined effects on cardiovascular disease (CVD) mortality and non-CVD mortality. Methods. We studied 4074 participants of the AGES–Reykjavik Study who were free from coronary heart disease, had a CAC score calculated from computed tomography scans and had data on mobility limitations and gait speed at baseline in 2002–2006 at a mean age of 76 years. Register-based mortality was available until 2009. Results. Odds for mobility limitation and slow gait increased according to the extent of CAC. Altogether 645 persons died during the follow-up. High CAC, mobility limitation and slow gait were independent predictors of CVD mortality and non-CVD mortality. The joint effect of CAC and gait speed on non-CVD mortality was synergistic, i.e. compared to having low CAC and normal gait, the joint effect of high CAC and slow gait exceeded the additive effect of these individual exposures on non-CVD mortality. For CVD mortality, the effect was additive i.e. the joint effect of high CAC and slow gait did not exceed the sum of the individual exposures. Conclusions. The extent of CAC and decreased physical performance were independent predictors of mortality and the joint presence of these risk factors increased the risk of non-CVD mortality above and beyond the individual effects. ...
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Showing items with similar title or keywords.
Mortality Risk among Older People Who Did Versus Did Not Sustain a Fracture : Baseline Prefracture Strength and Gait Speed as Predictors in a 15-Year Follow-Up Koivunen, Kaisa; Sillanpää, Elina; von Bonsdorff, Mikaela; Sakari, Ritva; Törmäkangas, Timo; Rantanen, Taina (Oxford University Press; The Gerontological Society of America, 2020)BACKGROUND: Physiological reserve, as indicated by muscle strength and gait speed, may be especially determinant of survival in people who are exposed to a health stressor. We studied whether the association between ...
Aktiivinen elää pidempään : fyysinen aktiivisuus, sydänsairaudet ja kokonaiskuolleisuus iäkkäillä ihmisillä Äijö, Marja (University of Jyväskylä, 2015)
Leisure Time Physical Activity and Sleep Predict Mortality in Men Irrespective of Background in Competitive Sports Wennman, Heini; Kronholm, Erkki; Heinonen, Olli; Kujala, Urho; Kaprio, Jaakko; Partonen, Timo; Bäckmand, Heli; Sarna, Seppo; Borodulin, Katja (Wolters Kluwer, 2017)Introduction: Physical activity and sleep are closely related behaviors with suggested synergistic influence on cardiovascular health. Physical activity potentially modifies associations between sleep and mortality. Our ...
Temporal changes in personal activity intelligence and mortality : data from the aerobics center longitudinal study Nauman, Javaid; Arena, Ross; Zisko, Nina; Sui, Xuemei; Lavie, Carl J.; Laukkanen, Jari A.; Blair, Steven N.; Dunn, Patrick; Nes, Bjarne M.; Tari, Atefe R.; Stensvold, Dorthe; Whitsel, Laurie P.; Wisløff, Ulrik (Elsevier, 2021)Background Personal activity intelligence (PAI) is a metric developed to simplify a physically active lifestyle for the participants. Regardless of following today's advice for physical activity, a PAI score ≥100 per week ...
Nauman, Javaid; Sui, Xuemei; Lavie, Carl J.; Wen, Chi Pang; Laukkanen, Jari A.; Blair, Steven N.; Dunn, Patrick; Arena, Ross; Wisløff, Ulrik (Elsevier, 2021)Importance Personal activity intelligence (PAI) is a novel activity metric that can be integrated into self-assessment heart rate devices, and translates heart rate variations during exercise into a weekly score. Previous ...