Filopodia-like actin cables position nuclei in association with perinuclear actin in Drosophila nurse cells

Huelsmann, Sven; Ylänne, Jari; Brown, Nicholas H.

doi:10.1016/j.devcel.2013.08.014

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Huelsmann, S., Ylänne, J., & Brown, N. H. (2013). Filopodia-like actin cables position nuclei in association with perinuclear actin in Drosophila nurse cells. Developmental Cell, 26(6), 604-615. https://doi.org/10.1016/j.devcel.2013.08.014

Julkaistu sarjassa

Developmental Cell

Tekijät

Huelsmann, Sven |

Ylänne, Jari |

Brown, Nicholas H.

Päivämäärä

2013

Oppiaine

Solu- ja molekyylibiologia Cell and Molecular Biology

Tekijänoikeudet

© 2013 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

Controlling the position of the nucleus is vital for a number of cellular processes from yeast to humans. In Drosophila nurse cells, nuclear positioning is crucial during dumping, when nurse cells contract and expel their contents into the oocyte. We provide evidence that in nurse cells, continuous filopodia-like actin cables, growing from the plasma membrane and extending to the nucleus, achieve nuclear positioning. These actin cables move nuclei away from ring canals. When nurse cells contract, actin cables associate laterally with the nuclei, in some cases inducing nuclear turning so that actin cables become partially wound around the nuclei. Our data suggest that a perinuclear actin meshwork connects actin cables to nuclei via actin-crosslinking proteins such as the filamin Cheerio. We provide a revised model for how actin structures position nuclei in nurse cells, employing evolutionary conserved machinery.

Julkaisija

Cell Press

ISSN Hae Julkaisufoorumista

1534-5807

Lisenssi

© 2013 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

Ellei muuten mainita, aineiston lisenssi on © 2013 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.

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