Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice
Kainulainen, H., Papaioannou, K. G., Silvennoinen, M., Autio, R., Saarela, J., Oliveira, B. M., Nyqvist, M., Pasternack, A., Hoen, P. A. ’., Kujala, U., Ritvos, O., & Hulmi, J. (2015). Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. Molecular and cellular endocrinology, 399(January), 131-142. https://doi.org/10.1016/j.mce.2014.10.001
Julkaistu sarjassa
Molecular and cellular endocrinologyTekijät
Päivämäärä
2015Oppiaine
LiikuntafysiologiaFysioterapiaLiikuntalääketiedeExercise PhysiologyPhysiotherapySports and Exercise MedicineTekijänoikeudet
© Elsevier Ltd. This is a final draft version of an article whose final and definitive form has been published by Elsevier.
Duchenne Muscular Dystrophy is characterized by muscle wasting and decreased aerobic
metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined
counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble
activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in
combination for seven weeks in dystrophic mdx mice. Expression microarray analysis revealed
decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice.
This was not due to reduced home-cage physical activity, and was further downregulated upon
sActRIIB-Fc treatment in enlarged muscles. However, exercise activated pathways of aerobic
metabolism and counteracted the negative effects of sActRIIB-Fc. Exercise and sActRIIB-Fc
synergistically increased expression of major urinary protein, but exercise blocked sActRIIB-Fc
induced phosphorylation of STAT5 in gastrocnemius muscle. In conclusion, exercise alone or in
combination with myostatin/activin blocking corrects aerobic gene expression profiles of dystrophic
muscle towards healthy wild type mice profiles.
...
Julkaisija
Elsevier Ireland LtdISSN Hae Julkaisufoorumista
0303-7207Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/23930514
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