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Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine
(2010)
Kainate receptor antagonists have potential as therapeutic agents in a number of neuropathologies. Synthetic modification of the convulsant marine toxin neodysiherbaine A (NDH) previously yielded molecules with a diverse ...
Filopodia-like actin cables position nuclei in association with perinuclear actin in Drosophila nurse cells
(Cell Press, 2013)
Controlling the position of the nucleus is vital for a number of cellular processes from yeast to humans. In Drosophila nurse cells, nuclear positioning is crucial during dumping, when nurse cells contract and expel their ...
How many gold atoms make gold metal?
(European Physical Society, EDP Sciences, 2015)
It is well known that a piece of gold is an excellent metal: it conducts heat and
electricity, it is malleable to work out for jewellery or thin coatings, and it has the
characteristic golden colour. How do these everyday ...
Value of information in multiple criteria decision making : an application to forest conservation
(Springer Berlin Heidelberg, 2019)
Developing environmental conservation plans involves assessing trade-offs between the benefits and costs of conservation. The benefits of conservation can be established with ecological inventories or estimated based on ...
Surface characteristics control the attachment and functionality of (chimeric) avidin
(American Chemical Society, 2018)
The physical adsorption (physisorption) of proteins to surfaces is an important but incompletely understood factor in many biological processes and is of increasing significance in bionanotechnology as well. Avidin is an ...
Exploring kainate receptor pharmacology using molecular dynamics simulations
(2010)
Ionotropic glutamate receptors (iGluRs) are enticing targets for pharmaceutical research; however, the search for selective ligands is a laborious experimental process. Here we introduce a purely computational procedure ...
Repeated evolution of camouflage in speciose desert rodents
(Nature Publishing Group, 2017)
There are two main factors explaining variation among species and the evolution of characters along
phylogeny: adaptive change, including phenotypic and genetic responses to selective pressures,
and phylogenetic inertia, ...
Transfer cross sections at near-barrier energy for the 24Mg + 90,92Zr systems
(Jagellonian University, 2018)
We have tested the hypothesis that for systems 24Mg + 90,92Zr, the shape of the barrier height distribution is not influenced by transfers processes. The experiment was performed using the ICARE detector system at the ...
Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells
(Public Library of Science, 2015)
Small RNA molecules, including microRNAs (miRNAs), play critical roles in regulating pluripotency,
proliferation and differentiation of embryonic stem cells. miRNA-offset RNAs
(moRNAs) are similar in length to miRNAs, ...
Novel activities of safe-in-human broad-spectrum antiviral agents
(Elsevier, 2018)
According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, ...