Näytä suppeat kuvailutiedot

dc.contributor.authorZávodná, Aneta
dc.contributor.authorJanovský, Petr
dc.contributor.authorKolařík, Václav
dc.contributor.authorWard, Jas S.
dc.contributor.authorPrucková, Zdeňka
dc.contributor.authorRouchal, Michal
dc.contributor.authorRissanen, Kari
dc.contributor.authorVícha, Robert
dc.date.accessioned2024-11-27T12:15:50Z
dc.date.available2024-11-27T12:15:50Z
dc.date.issued2024
dc.identifier.citationZávodná, A., Janovský, P., Kolařík, V., Ward, J. S., Prucková, Z., Rouchal, M., Rissanen, K., & Vícha, R. (2024). Allosteric release of cucurbit[6]uril from a rotaxane using a molecular signal. <i>Chemical Science</i>, <i>Early online</i>. <a href="https://doi.org/10.1039/d4sc03970j" target="_blank">https://doi.org/10.1039/d4sc03970j</a>
dc.identifier.otherCONVID_244066748
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/98654
dc.description.abstractRotaxanes can be regarded as storage systems for their wheel components, which broadens their application potential as a complement to the supramolecular systems that retain a mechanically interlocked structure. However, utilising rotaxanes in this way requires a method to release the wheel while preserving the integrity of all molecular constituents. Herein, we present simple rotaxanes based on cucurbit[6]uril (CB6), with an axis equipped with an additional binding motif that enables the binding of another macrocycle, cucurbit[7]uril (CB7). We demonstrate that the driving force behind the wheel dethreading originates from the binding of the signalling macrocycle to the allosteric site, leading to an increase in the system's strain. Consequently, the CB6 wheel leaves the rotaxane station overcoming the mechanical barrier. Portal–portal repulsive interactions between the two cucurbituril units play a crucial role in this process. Thus, the repulsive strength and the related rate of slipping off can be finely tuned by the length of the allosteric binding motif. Finally, we show that the CB6 wheel can be utilised within complexes with other guests in the mixture once released from the rotaxane.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofseriesChemical Science
dc.rightsCC BY-NC 4.0
dc.titleAllosteric release of cucurbit[6]uril from a rotaxane using a molecular signal
dc.typeresearch article
dc.identifier.urnURN:NBN:fi:jyu-202411277478
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2041-6520
dc.relation.volumeEarly online
dc.type.versionpublishedVersion
dc.rights.copyright© 2024 The Author(s). Published by the Royal Society of Chemistry
dc.rights.accesslevelopenAccessfi
dc.type.publicationarticle
dc.subject.ysokompleksiyhdisteet
dc.subject.ysoorgaaninen kemia
dc.subject.ysokemiallinen synteesi
dc.subject.ysosupramolekulaarinen kemia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p30190
jyx.subject.urihttp://www.yso.fi/onto/yso/p11902
jyx.subject.urihttp://www.yso.fi/onto/yso/p8468
jyx.subject.urihttp://www.yso.fi/onto/yso/p37759
dc.rights.urlhttps://creativecommons.org/licenses/by-nc/4.0/
dc.relation.doi10.1039/d4sc03970j
jyx.fundinginformationThe financial support of this work by the Internal Funding Agency of Tomas Bata University in Zlín, project IGA/FT/2024/001, and the University of Jyväskylä is gratefully acknowledged.
dc.type.okmA1


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