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dc.contributor.authorSavikangas, Tiina
dc.contributor.authorValadão, Pedro
dc.contributor.authorHaapala, Eero A.
dc.contributor.authorFinni, Taija
dc.date.accessioned2024-10-24T07:27:36Z
dc.date.available2024-10-24T07:27:36Z
dc.date.issued2024
dc.identifier.citationSavikangas, T., Valadão, P., Haapala, E. A., & Finni, T. (2024). Effects of multicomponent exercise intervention on cardiometabolic risk factors in children and young adults with cerebral palsy : a multiple-baseline trial. <i>BMC Sports Science, Medicine and Rehabilitation</i>, <i>16</i>, Article 219. <a href="https://doi.org/10.1186/s13102-024-01006-0" target="_blank">https://doi.org/10.1186/s13102-024-01006-0</a>
dc.identifier.otherCONVID_243604287
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/97664
dc.description.abstractBackground Adults with cerebral palsy (CP) have a high risk of cardiometabolic diseases. It is unknown whether this risk is elevated in young people with CP and whether exercise can reduce this risk. Therefore, we investigated the effects of the EXErcise for Cerebral Palsy (EXECP) intervention on cardiometabolic risk in children and young adults with CP and compared this risk to typically developing children and young adults (TDs). Methods Ambulatory male and female participants with spastic CP, aged 9–24 years, and age- and sex-matched TDs without musculoskeletal disorders were recruited. Participants with CP were measured at baseline, after a three-month control period manifesting normal development, and after the three-month strength, gait, and flexibility training intervention. TDs were measured at baseline and after the control period. They did not attend the intervention. Cardiometabolic risk factors included body weight, body fat percentage, and skeletal muscle mass index assessed with bioimpedance; resting systolic and diastolic blood pressure and aortic pulse wave velocity assessed with a non-invasive oscillometric device; fasting plasma high-density and low-density lipoprotein cholesterol, triglyceride, and glucose levels. Data were analyzed with independent samples t-tests and linear mixed-effects models adjusted for sex and age. Results The study involved 18 participants with CP (13 males, 9–22 year, mean 14.2 ± 4.4) and 17 TDs (12 males, 9–22 year, mean 14.6 ± 4.3). At baseline, participants with CP had a 1.0 (95% confidence interval (CI) [-2.0, -0.0]) kg/m2 lower skeletal muscle mass index than TDs. During the control period, no statistically significant between-group differences were observed in the change of any outcome. In the CP group, body weight (β = 1.87, 95% CI [1.04, 2.70]), fat percentage (β = 1.22 [0.07, 2.37], and blood glucose (β = 0.19, 95% CI [0.01, 0.37]) increased, while diastolic blood pressure (β=-2.31, 95% CI [-4.55, -0.06]) and pulse wave velocity (β=-0.44, 95% CI [-0.73, -0.16]) decreased. In the TD group, only body weight increased (β = 0.85, 95% CI [0.01, 1.68]) statistically significantly. In the CP group, no changes were observed during the intervention. Conclusions Young people with and without CP do not exhibit significant differences in most cardiometabolic risk factors. EXECP intervention may attenuate some adverse development trajectories occurring without the intervention but greater volume and intensity of aerobic exercise may be needed to reduce cardiometabolic risk.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofseriesBMC Sports Science, Medicine and Rehabilitation
dc.rightsCC BY 4.0
dc.subject.othercerebral palsy
dc.subject.otherexercise
dc.subject.otherstrength training
dc.subject.othergait training
dc.subject.othercardiometabolic health
dc.subject.otherbody composition
dc.subject.otherblood pressure
dc.subject.otherlipids
dc.subject.otherglucose
dc.titleEffects of multicomponent exercise intervention on cardiometabolic risk factors in children and young adults with cerebral palsy : a multiple-baseline trial
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202410246521
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2052-1847
dc.relation.volume16
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2024
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber327288
dc.relation.grantnumber311877
dc.relation.grantnumber326988
dc.relation.grantnumberPHD00321
dc.subject.ysoCP-oireyhtymä
dc.subject.ysoglukoosi
dc.subject.ysovoimaharjoittelu
dc.subject.ysolipidit
dc.subject.ysosydän- ja verisuonitaudit
dc.subject.ysokehonkoostumus
dc.subject.ysoverenpaine
dc.subject.ysoharjoittelu
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p13394
jyx.subject.urihttp://www.yso.fi/onto/yso/p18742
jyx.subject.urihttp://www.yso.fi/onto/yso/p16233
jyx.subject.urihttp://www.yso.fi/onto/yso/p4799
jyx.subject.urihttp://www.yso.fi/onto/yso/p9886
jyx.subject.urihttp://www.yso.fi/onto/yso/p26989
jyx.subject.urihttp://www.yso.fi/onto/yso/p7682
jyx.subject.urihttp://www.yso.fi/onto/yso/p26412
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1186/s13102-024-01006-0
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderCerebral Palsy Allianceen
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderCerebral Palsy Alliancefi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramResearch profiles, AoFen
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramOthersen
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramProfilointi, SAfi
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundingprogramMuutfi
jyx.fundinginformationThe preparation of this manuscript was supported by the Ministry of Education and Culture (OKM/28/626/2022). The data collection of the EXECP study also was supported by the Olvi Foundation, the Research Foundation of Cerebral Palsy Alliance (PHD00321), the Finnish Cultural Foundation, Jane and Aatos Erkko Foundation (602.274), and the Research Council of Finland (296240, 307250, 327288, 311877, 326988).
dc.type.okmA1


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