Directional selection, not the direction of selection, affects telomere length and copy number at ribosomal RNA loci
Sadler, D. E., Watts, P., & Uusi-Heikkilä, S. (2024). Directional selection, not the direction of selection, affects telomere length and copy number at ribosomal RNA loci. Scientific Reports, 14, Article 12162. https://doi.org/10.1038/s41598-024-63030-x
Published in
Scientific ReportsDate
2024Copyright
© Te Author(s) 2024
Many fisheries exert directional selection on traits such as body size and growth rate. Whether directional selection impacts regions of the genome associated with traits related to growth is unknown. To address this issue, we characterised copy number variation in three regions of the genome associated with cell division, (1) telomeric DNA, (2) loci transcribed as ribosomal RNA (rDNA), and (3) mitochondrial DNA (mtDNA), in three selection lines of zebrafish reared at three temperatures (22 °C, 28 °C, and 34 °C). Selection lines differed in (1) the direction of selection (two lines experienced directional selection for large or small body size) and (2) whether they experienced any directional selection itself. Lines that had experienced directional selection were smaller, had lower growth rate, shorter telomeres, and lower rDNA copy number than the line that experiencing no directional selection. Neither telomere length nor rDNA copy number were affected by temperature. In contrast, mtDNA content increased at elevated temperature but did not differ among selection lines. Though directional selection impacts rDNA and telomere length, direction of such selection did not matter, whereas mtDNA acts as a stress marker for temperature. Future work should examine the consequences of these genomic changes in natural fish stocks.
...
![showless](/themes/JYX2//images/showless.png)
![showmore](/themes/JYX2//images/showmore.png)
Publisher
SpringerISSN Search the Publication Forum
2045-2322Keywords
Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/220709718
Metadata
Show full item recordRelated funder(s)
Research Council of FinlandFunding program(s)
Academy Programme, AoF; Academy Research Fellow, AoF; Academy Project, AoFAdditional information about funding
We thank the Academy of Finland for funding (grant numbers 325107 to SUH; 324602 and 329883 to PCW).License
Related items
Showing items with similar title or keywords.
-
Genome-Wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
Li, Chen; Stoma, Svetlana; Lotta, Luca A.; Warner, Sophie; Albrecht, Eva; Allione, Alessandra; Arp, Pascal P.; Broer, Linda; Buxton, Jessica L.; Da Silva Couto Alves, Alexessander; Deelen, Joris; Fedko, Iryna O.; Gordon, Scott D.; Jiang, Tao; Karlsson, Robert; Kerrison, Nicola; Loe, Taylor K.; Mangino, Massimo; Milaneschi, Yuri; Miraglio, Benjamin; Pervjakova, Natalia; Russo, Alessia; Surakka, Ida; van der Spek, Ashley; Verhoeven, Josine E.; Amin, Najaf; Beekman, Marian; Blakemore, Alexandra I.; Canzian, Federico; Hamby, Stephen E.; Hottenga, Jouke-Jan; Jones, Peter D.; Jousilahti, Pekka; Mägi, Reedik; Medland, Sarah E.; Montgomery, Grant W.; Nyholt, Dale R.; Perola, Markus; Pietiläinen, Kirsi H.; Salomaa, Veikko; Sillanpää, Elina; Suchiman, H. Eka; van Heemst, Diana; Willemsen, Gonneke; Agudo, Antonio; Boeing, Heiner; Boomsma, Dorret I.; Chirlaque, Maria-Dolores; Fagherazzi, Guy; Ferrari, Pietro; Franks, Paul; Gieger, Christian; Eriksson, Johan Gunnar; Gunter, Marc; Hägg, Sara; Hovatta, Iiris; Imaz, Liher; Kaprio, Jaakko; Kaaks, Rudolf; Key, Timothy; Krogh, Vittorio; Martin, Nicholas G.; Melander, Olle; Metspalu, Andres; Moreno, Concha; Onland-Moret, N. Charlotte; Nilsson, Peter; Ong, Ken K.; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Pedersen, Nancy L.; Penninx, Brenda W. J. H.; Quirós, J. Ramón; Jarvelin, Marjo Riitta; Rodríguez-Barranco, Miguel; Scott, Robert A.; Severi, Gianluca; Slagboom, P. Eline; Spector, Tim D.; Tjonneland, Anne; Trichopoulou, Antonia; Tumino, Rosario; Uitterlinden, André G.; van der Schouw, Yvonne T.; van Duijn, Cornelia M.; Weiderpass, Elisabete; Denchi, Eros Lazzerini; Matullo, Giuseppe; Butterworth, Adam S.; Danesh, John; Samani, Nilesh J.; Wareham, Nicholas J.; Nelson, Christopher P.; Langenberg, Claudia; Codd, Veryan (Cell Press, 2020)Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale ... -
Genetic colour variation visible for predators and conspecifics is concealed from humans in a polymorphic moth
Nokelainen, Ossi; Galarza, Juan A.; Kirvesoja, Jimi; Suisto, Kaisa; Mappes, Johanna (Wiley-Blackwell, 2022)The definition of colour polymorphism is intuitive: genetic variants express discretely coloured phenotypes. This classification is, however, elusive as humans form subjective categories or ignore differences that cannot ... -
Heterozygote advantage and pleiotropy contribute to intraspecific color trait variability
De Pasqual, Chiara; Suisto, Kaisa; Kirvesoja, Jimi; Gordon, Swanne; Ketola, Tarmo; Mappes, Johanna (John Wiley & Sons, 2022)The persistence of intrapopulation phenotypic variation typically requires some form of balancing selection since drift and directional selection eventually erode genetic variation. Heterozygote advantage remains a classic ... -
Cold adaptation drives population genomic divergence in the ecological specialist, Drosophila montana
Wiberg, R. A. W.; Tyukmaeva, V.; Hoikkala, A.; Ritchie, M. G.; Kankare, M. (Wiley, 2021)Detecting signatures of ecological adaptation in comparative genomics is challenging, but analysing population samples with characterised geographic distributions, such as clinal variation, can help identify genes showing ... -
Rich resource environment of fish farms facilitates phenotypic variation and virulence in an opportunistic fish pathogen
Pulkkinen, Katja; Ketola, Tarmo; Laakso, Jouni; Mappes, Johanna; Sundberg, Lotta‐Riina (Wiley-Blackwell, 2022)Phenotypic variation is suggested to facilitate the persistence of environmentally growing pathogens under environmental change. Here we hypothesized that the intensive farming environment induces higher phenotypic variation ...