dc.contributor.author | Verma, Prachi | |
dc.contributor.author | Pallerla, Rajanish, R. | |
dc.contributor.author | Rolig, Aino | |
dc.contributor.author | Pihko, Petri, M. | |
dc.date.accessioned | 2024-05-03T07:30:04Z | |
dc.date.available | 2024-05-03T07:30:04Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Verma, P., Pallerla, R., Rolig, A., & Pihko, P. (2024). Humilisin E : Strategy for the Synthesis and Access to the Functionalized Bicyclic Core. <i>Journal of Organic Chemistry</i>, <i>Early online</i>. <a href="https://doi.org/10.1021/acs.joc.4c00358" target="_blank">https://doi.org/10.1021/acs.joc.4c00358</a> | |
dc.identifier.other | CONVID_213447606 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/94670 | |
dc.description.abstract | Humilisin E is a diterpenoid possessing a rare epoxidized cyclononene trans-fused with a bicyclo[3.2.0]heptane core. We have identified the P atropisomer of the corresponding cyclononadiene as a potential biosynthetic/synthetic precursor to humilisin E and reported two different strategies for the stereocontrolled synthesis of the appropriately functionalized bicyclic cores of humilisin E. The first route involves a Stork epoxynitrile cyclization via a Mg alkoxide, and the second, more stereoselective approach utilizes the Wolff rearrangement as the key step. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society (ACS) | |
dc.relation.ispartofseries | Journal of Organic Chemistry | |
dc.rights | CC BY 4.0 | |
dc.title | Humilisin E : Strategy for the Synthesis and Access to the Functionalized Bicyclic Core | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202405033297 | |
dc.contributor.laitos | Kemian laitos | fi |
dc.contributor.laitos | Department of Chemistry | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.issn | 0022-3263 | |
dc.relation.volume | Early online | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © XXXX The Authors. Published by American Chemical Society | |
dc.rights.accesslevel | openAccess | fi |
dc.relation.grantnumber | 339892 | |
dc.relation.grantnumber | | |
dc.relation.grantnumber | 322899 | |
dc.relation.grantnumber | 307624 | |
dc.subject.yso | kemiallinen synteesi | |
dc.subject.yso | orgaaniset yhdisteet | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p8468 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p3841 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1021/acs.joc.4c00358 | |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Technology Industries of Finland Centennial Foundation | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Teknologiateollisuuden 100-vuotissäätiö | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Foundation | en |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Academy Programme, AoF | en |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundingprogram | Säätiö | fi |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundingprogram | Akatemiaohjelma, SA | fi |
jyx.fundinginformation | Support from the University of Jyväskylä, Research Council Finland (Projects 307624, 322899 and 339892), and Project DIGIPOWER (Technology Industries of Finland Centennial Foundation and Jane & Aatos Erkko Foundation) is gratefully acknowledged. | |
dc.type.okm | A1 | |