dc.contributor.author | Raza, Ghulam Shere | |
dc.contributor.author | Kaya, Yağmur | |
dc.contributor.author | Stenbäck, Ville | |
dc.contributor.author | Sharma, Ravikant | |
dc.contributor.author | Sodum, Nalini | |
dc.contributor.author | Mutt Shivaprakash, Jagalur | |
dc.contributor.author | Gagnon, Dominique D. | |
dc.contributor.author | Tulppo, Mikko | |
dc.contributor.author | Järvelin, Marjo‐Riitta | |
dc.contributor.author | Herzig, Karl‐Heinz | |
dc.contributor.author | Mäkelä, Kari A. | |
dc.date.accessioned | 2024-03-05T07:57:34Z | |
dc.date.available | 2024-03-05T07:57:34Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Raza, G. S., Kaya, Y., Stenbäck, V., Sharma, R., Sodum, N., Mutt Shivaprakash, J., Gagnon, D. D., Tulppo, M., Järvelin, M., Herzig, K., & Mäkelä, K. A. (2024). Effect of Aerobic Exercise and Time‐Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High‐Fat Diet. <i>Molecular Nutrition and Food Research</i>, <i>68</i>(5), Article 2300465. <a href="https://doi.org/10.1002/mnfr.202300465" target="_blank">https://doi.org/10.1002/mnfr.202300465</a> | |
dc.identifier.other | CONVID_207408207 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/93803 | |
dc.description.abstract | Scope
Diet and exercise are significant players in obesity and metabolic diseases. Time-restricted feeding (tRF) has been shown to improve metabolic responses by regulating circadian clocks but whether it acts synergically with exercise remains unknown. It is hypothesized that forced exercise alone or combined with tRF alleviates obesity and its metabolic complications.
Methods and results
Male C57bl6 mice are fed with high-fat or a control diet for 12 weeks either ad libitum or tRF for 10 h during their active period. High-fat diet (HFD)-fed mice are divided into exercise (treadmill for 1 h at 12 m min−1 alternate days for 9 weeks and 16 m min−1 daily for the following 3 weeks) and non-exercise groups. tRF and tRF-Ex significantly decreased body weight, food intake, and plasma lipids, and improved glucose tolerance. However, exercise reduced only body weight and plasma lipids. tRF and tRF-Ex significantly downregulated Fasn, Hmgcr, and Srebp1c, while exercise only Hmgcr. HFD feeding disrupted clock genes, but exercise, tRF, and tRF-Ex coordinated the circadian clock genes Bmal1, Per2, and Rev-Erbα in the liver, adipose tissue, and skeletal muscles.
Conclusion
HFD feeding disrupted clock genes in the peripheral organs while exercise, tRF, and their combination restored clock genes and improved metabolic consequences induced by high-fat diet feeding. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Wiley-VCH Verlag | |
dc.relation.ispartofseries | Molecular Nutrition and Food Research | |
dc.rights | CC BY 4.0 | |
dc.title | Effect of Aerobic Exercise and Time‐Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High‐Fat Diet | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202403052270 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.issn | 1613-4125 | |
dc.relation.numberinseries | 5 | |
dc.relation.volume | 68 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2024 The Authors. Molecular Nutrition & Food Research published by
Wiley-VCH GmbH. | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | ravitsemus | |
dc.subject.yso | aineenvaihduntahäiriöt | |
dc.subject.yso | aineenvaihdunta | |
dc.subject.yso | ruokavaliot | |
dc.subject.yso | lihavuus | |
dc.subject.yso | liikunta | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5748 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p6239 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p3066 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p3790 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p823 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p916 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1002/mnfr.202300465 | |
jyx.fundinginformation | The study was supported partially by Research Council of Finland Profi6 funding decision Profi6 336449 for the salary of GSR. YK and RS were supported in part by EDUFI Grants (Finnish National Agency for Education). | |
dc.type.okm | A1 | |