Näytä suppeat kuvailutiedot

dc.contributor.authorJokela, Tiina A.
dc.contributor.authorKarppinen, Jari E.
dc.contributor.authorKärkkäinen, Minta
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorWalker, Simon
dc.contributor.authorSeppälä, Toni T.
dc.contributor.authorLaakkonen, Eija K.
dc.date.accessioned2024-02-14T12:24:05Z
dc.date.available2024-02-14T12:24:05Z
dc.date.issued2024
dc.identifier.citationJokela, T. A., Karppinen, J. E., Kärkkäinen, M., Mecklin, J.-P., Walker, S., Seppälä, T. T., & Laakkonen, E. K. (2024). Circulating metabolome landscape in Lynch syndrome. <i>Cancer and Metabolism</i>, <i>12</i>, Article 4. <a href="https://doi.org/10.1186/s40170-024-00331-9" target="_blank">https://doi.org/10.1186/s40170-024-00331-9</a>
dc.identifier.otherCONVID_206974543
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/93387
dc.description.abstractCirculating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes. Genetic background increases cancer risk in individuals with Lynch syndrome; however, not all carriers develop cancer. Various lifestyle factors can influence Lynch syndrome cancer risk, and lifestyle choices actively shape systemic metabolism, with circulating metabolites potentially serving as the mechanical link between lifestyle and cancer risk. This study aims to characterize the circulating metabolome of Lynch syndrome carriers, shedding light on the energy metabolism status in this cancer predisposition syndrome. This study consists of a three-group cross-sectional analysis to compare the circulating metabolome of cancer-free Lynch syndrome carriers, sporadic colorectal cancer (CRC) patients, and healthy non-carrier controls. We detected elevated levels of circulating cholesterol, lipids, and lipoproteins in LS carriers. Furthermore, we unveiled that Lynch syndrome carriers and CRC patients displayed similar alterations compared to healthy non-carriers in circulating amino acid and ketone body profiles. Overall, cancer-free Lynch syndrome carriers showed a unique circulating metabolome landscape. This study provides valuable insights into the systemic metabolic landscape of Lynch syndrome individuals. The findings hint at shared metabolic patterns between cancer-free Lynch syndrome carriers and CRC patients.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBiomed Central
dc.relation.ispartofseriesCancer and Metabolism
dc.rightsCC BY 4.0
dc.subject.othermetabolomic biomarkers
dc.subject.otherDNA mismatch repair defciency
dc.subject.otherhereditary cancer
dc.subject.otherlipid metabolism
dc.subject.othercholesterol metabolism
dc.subject.othercirculating amino acids
dc.subject.otherketone bodies
dc.subject.otherGlycA
dc.titleCirculating metabolome landscape in Lynch syndrome
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202402141867
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineFyysinen aktiivisuus eliniän aikanafi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiainePhysical activity through life spanen
dc.contributor.oppiaineSchool of Wellbeingen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2049-3002
dc.relation.volume12
dc.type.versionpublishedVersion
dc.rights.copyright© 2024 the Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber330281
dc.relation.grantnumber335249
dc.relation.grantnumber101026706
dc.relation.grantnumber101026706
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/101026706/EU//cmiRCan
dc.subject.ysosyöpätaudit
dc.subject.ysoaineenvaihdunta
dc.subject.ysoperinnölliset taudit
dc.subject.ysoaineenvaihduntahäiriöt
dc.subject.ysokolesteroli
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p678
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p19997
jyx.subject.urihttp://www.yso.fi/onto/yso/p6239
jyx.subject.urihttp://www.yso.fi/onto/yso/p10609
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1186/s40170-024-00331-9
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderEuropean Commissionen
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderEuroopan komissiofi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramMSCA Individual Fellowship (IF)en
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramMSCA Individual Fellowship (IF)fi
jyx.fundinginformationOpen Access funding provided by University of Jyväskylä (JYU). This work was supported by T.J.-the EU Marie Skłodowska-Curie Actions [Grant agreement ID: 101026706], S.W. the Finnish Cultural Foundation (grant #00211177), T.T.S.-research grants from Jane and Aatos Erkko Foundation, Sigrid Juselius Foundation, Finnish Medical Foundation, Emil Aaltonen Foundation, Cancer Foundation Finland, Relander Foundation, and state research funding. E.K.L Academy of Finland #335249 and #330281 and E.K.L: University of Jyväskylä.
dc.type.okmA1


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