Circulating metabolome landscape in Lynch syndrome
Jokela, T. A., Karppinen, J. E., Kärkkäinen, M., Mecklin, J.-P., Walker, S., Seppälä, T. T., & Laakkonen, E. K. (2024). Circulating metabolome landscape in Lynch syndrome. Cancer and Metabolism, 12, Article 4. https://doi.org/10.1186/s40170-024-00331-9
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Cancer and MetabolismAuthors
Date
2024Discipline
Fyysinen aktiivisuus eliniän aikanaHyvinvoinnin tutkimuksen yhteisöLiikuntalääketiedeGerontologia ja kansanterveysPhysical activity through life spanSchool of WellbeingSports and Exercise MedicineGerontology and Public HealthCopyright
© 2024 the Authors
Circulating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes. Genetic background increases cancer risk in individuals with Lynch syndrome; however, not all carriers develop cancer. Various lifestyle factors can influence Lynch syndrome cancer risk, and lifestyle choices actively shape systemic metabolism, with circulating metabolites potentially serving as the mechanical link between lifestyle and cancer risk. This study aims to characterize the circulating metabolome of Lynch syndrome carriers, shedding light on the energy metabolism status in this cancer predisposition syndrome.
This study consists of a three-group cross-sectional analysis to compare the circulating metabolome of cancer-free Lynch syndrome carriers, sporadic colorectal cancer (CRC) patients, and healthy non-carrier controls. We detected elevated levels of circulating cholesterol, lipids, and lipoproteins in LS carriers. Furthermore, we unveiled that Lynch syndrome carriers and CRC patients displayed similar alterations compared to healthy non-carriers in circulating amino acid and ketone body profiles. Overall, cancer-free Lynch syndrome carriers showed a unique circulating metabolome landscape.
This study provides valuable insights into the systemic metabolic landscape of Lynch syndrome individuals. The findings hint at shared metabolic patterns between cancer-free Lynch syndrome carriers and CRC patients.
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Biomed CentralISSN Search the Publication Forum
2049-3002Keywords
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https://converis.jyu.fi/converis/portal/detail/Publication/206974543
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- Liikuntatieteiden tiedekunta [3076]
Related funder(s)
Research Council of Finland; European CommissionFunding program(s)
Academy Project, AoF; Research costs of Academy Research Fellow, AoF; MSCA Individual Fellowship (IF)
The content of the publication reflects only the author’s view. The funder is not responsible for any use that may be made of the information it contains.
Additional information about funding
Open Access funding provided by University of Jyväskylä (JYU). This work was supported by T.J.-the EU Marie Skłodowska-Curie Actions [Grant agreement ID: 101026706], S.W. the Finnish Cultural Foundation (grant #00211177), T.T.S.-research grants from Jane and Aatos Erkko Foundation, Sigrid Juselius Foundation, Finnish Medical Foundation, Emil Aaltonen Foundation, Cancer Foundation Finland, Relander Foundation, and state research funding. E.K.L Academy of Finland #335249 and #330281 and E.K.L: University of Jyväskylä. ...License
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