Näytä suppeat kuvailutiedot

dc.contributor.authorBrila, Ilze
dc.contributor.authorLavrinienko, Anton
dc.contributor.authorTukalenko, Eugene
dc.contributor.authorKallio, Eva R.
dc.contributor.authorMappes, Tapio
dc.contributor.authorWatts, Phillip C.
dc.date.accessioned2024-01-26T07:46:40Z
dc.date.available2024-01-26T07:46:40Z
dc.date.issued2023
dc.identifier.citationBrila, I., Lavrinienko, A., Tukalenko, E., Kallio, E. R., Mappes, T., & Watts, P. C. (2023). Idiosyncratic effects of coinfection on the association between systemic pathogens and the gut microbiota of a wild rodent, the bank vole Myodes glareolus. <i>Journal of Animal Ecology</i>, <i>92</i>(4), 826-837. <a href="https://doi.org/10.1111/1365-2656.13869" target="_blank">https://doi.org/10.1111/1365-2656.13869</a>
dc.identifier.otherCONVID_164504042
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/93072
dc.description.abstractThe effects of systemic pathogens on gut microbiota of wild animals are poorly understood. Furthermore, coinfections are the norm in nature, yet most studies of pathogen–microbiota interactions focus on effects of single pathogen infections on gut microbiota. We examined the effects of four systemic pathogens (bacteria Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato, apicomplexan protozoa Babesia microti and Puumala orthohantavirus) and coinfections among them on the (bacterial) gut microbiota of wild bank voles Myodes glareolus. We hypothesized that: (1) the effects of coinfection on gut microbiota generally differ from those of a single pathogen infection, (2) systemic pathogens have individual (i.e. distinct) associations with gut microbiota, which are modified by coinfection and (3) the effects of coinfection (compared with those of single infection) are idiosyncratic (i.e. pathogen-specific). The gut microbiota of coinfected bank voles differed from that of single pathogen infected individuals, although, as predicted, the effects of coinfections were unique for each pathogen. After accounting for coinfections, only Puumala orthohantavirus was associated with higher α-diversity; however, all pathogens affected gut microbiota ß-diversity in a pathogen-specific way, affecting both rare and abundant gut bacteria. Our results showed that the effects of systemic pathogens on host's gut microbiota vary depending on the pathogen species, resulting in idiosyncratic signatures of coinfection. Furthermore, our results emphasize that neglecting the impact of coinfections can mask patterns of pathogen–microbiota associations.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofseriesJournal of Animal Ecology
dc.rightsIn Copyright
dc.subject.otherApicomplexa
dc.subject.otherbacteria
dc.subject.othercoinfection
dc.subject.otherdisease ecology
dc.subject.othergut microbiota
dc.subject.otherhost–pathogen interactions
dc.subject.otherpathogens
dc.subject.othervirus
dc.titleIdiosyncratic effects of coinfection on the association between systemic pathogens and the gut microbiota of a wild rodent, the bank vole Myodes glareolus
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202401261560
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineResurssiviisausyhteisöfi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.contributor.oppiaineSchool of Resource Wisdomen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange826-837
dc.relation.issn0021-8790
dc.relation.numberinseries4
dc.relation.volume92
dc.type.versionacceptedVersion
dc.rights.copyright© 2022 The Authors. Journal of Animal Ecology © 2022 British Ecological Society.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber329334
dc.relation.grantnumber329308
dc.relation.grantnumber324605
dc.relation.grantnumber268670
dc.relation.grantnumber329332
dc.relation.grantnumber335651
dc.subject.ysosuolistomikrobisto
dc.subject.ysovirukset
dc.subject.ysotaudinaiheuttajat
dc.subject.ysoitiöeläimet
dc.subject.ysobakteerit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p37925
jyx.subject.urihttp://www.yso.fi/onto/yso/p1123
jyx.subject.urihttp://www.yso.fi/onto/yso/p8822
jyx.subject.urihttp://www.yso.fi/onto/yso/p37804
jyx.subject.urihttp://www.yso.fi/onto/yso/p1749
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1111/1365-2656.13869
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramJoint International Project, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramKV-yhteishanke, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundinginformationAcademy of Finland, Grant/Award Number: 268670, 324605, 326534, 329308, 329332, 329334 and 335651; BiodivERsA- Belmont Forum
dc.type.okmA1


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