The Adaptive Potential of Nonheritable Somatic Mutations
Majic, P., Erten, E. Y., & Payne, J. L. (2022). The Adaptive Potential of Nonheritable Somatic Mutations. American Naturalist, 200(6), 755-772. https://doi.org/10.1086/721766
Julkaistu sarjassa
American NaturalistPäivämäärä
2022Tekijänoikeudet
© 2022 The University of Chicago
The adaptive potential of nonheritable somatic mutations has received limited attention in traditional evolutionary theory because heritability is a fundamental pillar of Darwinian evolution. We hypothesized that the ability of a germline genotype to express a novel phenotype via nonheritable somatic mutations can be selectively advantageous and that this advantage will channel evolving populations toward germline genotypes that constitutively express the phenotype. We tested this hypothesis by simulating evolving populations of developing organisms with an impermeable germline-soma separation navigating a minimal fitness landscape. The simulations revealed the conditions under which nonheritable somatic mutations promote adaptation. Specifically, this can occur when the somatic mutation supply is high, when few cells with the advantageous somatic mutation are required to increase organismal fitness, and when the somatic mutation also confers a selective advantage at the cellular level. We therefore provide proof of principle that nonheritable somatic mutations can promote adaptive evolution via a process we call “somatic genotypic exploration.” We discuss the biological plausibility of this phenomenon as well as its evolutionary implications.
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We thank Peter Ashcroft for discussions and for his assistance with the probability-generating functions. We thank Steven A. Frank, David V. McLeod, and William S. Dewitt III as well as members of the Computational Biology and Theoretical Biology groups in the Institute of Integrative Biology at ETH Zurich for critical feedback and discussions. This work was funded by grants from the Swiss National Science Foundation (PP00P3_170604 to J.L.P. and P500PB_203022 to E.Y.E.), E.Y.E. was also funded by the National Institutes of Health (U54 CA217376) and the University Research Priority Program “Evolution in Action” of the University of Zurich (awarded to Hanna Kokko). ...Lisenssi
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