Stress hormone response to instrumented elective lumbar spine fusion surgery
Repo, J. P., Neva, M. H., Häkkinen, K., Pekkanen, L., Metso, S., & Häkkinen, A. H. (2023). Stress hormone response to instrumented elective lumbar spine fusion surgery. Journal of Orthopaedic Surgery, 31(3). https://doi.org/10.1177/10225536231201910
Julkaistu sarjassa
Journal of Orthopaedic SurgeryTekijät
Päivämäärä
2023Tekijänoikeudet
© 2023 the Authors
Purpose
To understand the systemic effect of major spine surgery, we investigated stress, anabolic and catabolic hormonal levels and their association with interleukin 6 (IL-6) in patients undergoing elective lumbar spine fusion surgery.
Methods
Blood samples were collected preoperatively, and at 1, 3, 42, 90 days postoperatively (POD) from 49 patients who underwent elective lumbar spine fusion surgery.
Results
Serum concentration of cortisol was below the preoperative value at POD 1 but did not differ from the baseline values thereafter. Adrenocorticotropic hormone (ACTH) decreased at PODs 1 and 3. Testosterone decreased at PODs 1 and 3 in men, and at POD 3 in women. Sex hormone-binding globulin decreased at PODs 1 and 3 in both genders. No changes were observed in free testosterone or growth hormone concentrations. Insulin-like growth factor 1 increased significantly above the preoperative level at PODs 42 and 90 in women, and at POD 42 in men. IL-6 was significantly elevated at PODs 1 and 3. Increases in IL-6 from the preoperative level to POD 1 correlated significantly with decreases of cortisol at POD 1 but not with ACTH.
Conclusions
There were only short-term stress hormonal changes after elective lumbar spine fusion surgery. Cortisol changes after elective lumbar spine surgery are transient and might be partly cytokine induced and non-ACTH driven since there was association between cortisol and IL-6 but not with ACTH and IL-6.
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Julkaisija
SAGE PublicationsISSN Hae Julkaisufoorumista
1022-5536Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/194276704
Metadata
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Lisätietoja rahoituksesta
The study is funded by the Competitive State Financing of the Expert Responsibility Area of Tampere University Hospital.Lisenssi
Samankaltainen aineisto
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