Dietary fat quality and serum androgen concentrations in middle-aged men
Wynne-Ellis, M. M., Mursu, J. J., Tuomainen, T.-P., Bertone-Johnson, E., Salonen, J. T., & Virtanen, J. K. (2024). Dietary fat quality and serum androgen concentrations in middle-aged men. European Journal of Clinical Nutrition, 78, 99-106. https://doi.org/10.1038/s41430-023-01358-9
Julkaistu sarjassa
European Journal of Clinical NutritionTekijät
Päivämäärä
2024Tekijänoikeudet
© The Author(s) 2023
Background/Objectives
Average testosterone concentrations in men have declined over the last few decades. The reasons for this are not fully known, but changes in dietary fat quality have been suggested to have a role. This study aimed to investigate the associations of different dietary fatty acids with serum androgen concentrations.
Subjects/Methods
A total of 2546 men with a mean age of 53 from the Kuopio Ischaemic Heart Disease Risk Factor Study were included in this cross-sectional study. Associations between dietary saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA) and trans (TFA) fatty acids and concentrations of serum total and free testosterone and steroid hormone binding globulin (SHBG) were analyzed with analysis of covariance and linear regression analysis. Associations of isocaloric replacement of nutrients and androgen concentrations were analyzed with multivariate nutrient-density models.
Results
After adjustment for age, examination year and energy intake, higher SFA intake was associated with higher serum total and free testosterone and SHBG concentrations, and higher PUFA intake with lower concentrations. However, the associations were attenuated and not statistically significant after further adjustments for potential confounders. MUFA and TFA intakes were not associated with androgen concentrations. In isocaloric substitution models, replacing dietary protein with SFA was associated with higher serum total testosterone and SHBG concentrations. After excluding men with history of CVD or diabetes (n = 1021), no statistically significant associations were found.
Conclusions
Dietary fat quality was not independently associated with serum androgen concentrations in middle-aged men. However, replacing protein with SFA may be associated with higher serum androgen concentrations.
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Julkaisija
Nature Publishing GroupISSN Hae Julkaisufoorumista
0954-3007Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/194320338
Metadata
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Lisätietoja rahoituksesta
Open access funding provided by University of Eastern Finland (including Kuopio University Hospital).Lisenssi
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