Effect of a Multicomponent Intervention on Hepatic Steatosis Is Partially Mediated by the Reduction of Intermuscular Abdominal Adipose Tissue in Children With Overweight or Obesity : The EFIGRO Project
Cadenas-Sanchez, C., Idoate, F., Cabeza, R., Villanueva, A., Rodríguez-Vigil, B., Medrano, M., Osés, M., Ortega, F. B., Ruiz, J. R., & Labayen, I. (2022). Effect of a Multicomponent Intervention on Hepatic Steatosis Is Partially Mediated by the Reduction of Intermuscular Abdominal Adipose Tissue in Children With Overweight or Obesity : The EFIGRO Project. Diabetes Care, 45(9), 1953-1960. https://doi.org/10.2337/dc21-2440
Julkaistu sarjassa
Diabetes CareTekijät
Päivämäärä
2022Tekijänoikeudet
© 2022 American Diabetes Association
OBJECTIVE
In adults, there is evidence that improvement of metabolic-associated fatty liver disease (MAFLD) depends on the reduction of myosteatosis. In children, in whom the prevalence of MAFLD is alarming, this muscle-liver crosstalk has not been tested. Therefore, we aimed to explore whether the effects of a multicomponent intervention on hepatic fat is mediated by changes in intermuscular abdominal adipose tissue (IMAAT) in children with overweight/obesity.
RESEARCH DESIGN AND METHODS
A total of 116 children with overweight/obesity were allocated to a 22-week family-based lifestyle and psychoeducational intervention (control group, n = 57) or the same intervention plus supervised exercise (exercise group, n = 59). Hepatic fat percentage and IMAAT were acquired by MRI at baseline and at the end of the intervention.
RESULTS
Changes in IMAAT explained 20.7% of the improvements in hepatic steatosis (P < 0.05). Only children who meaningfully reduced their IMAAT (i.e., responders) had improved hepatic steatosis at the end of the intervention (within-group analysis: responders −20% [P = 0.005] vs. nonresponders −1.5% [P = 0.803]). Between-group analysis showed greater reductions in favor of IMAAT responders compared with nonresponders (18.3% vs. 0.6%, P = 0.018), regardless of overall abdominal fat loss.
CONCLUSIONS
The reduction of IMAAT plays a relevant role in the improvement of hepatic steatosis after a multicomponent intervention in children with overweight/obesity. Indeed, only children who achieved a meaningful reduction in IMAAT at the end of the intervention had a reduced percentage of hepatic fat independent of abdominal fat loss. Our findings suggest that abdominal muscle fat infiltration could be a therapeutic target for the treatment of MAFLD in childhood.
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Julkaisija
American Diabetes AssociationISSN Hae Julkaisufoorumista
0149-5992Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/189070470
Metadata
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Lisätietoja rahoituksesta
This project was funded by the Spanish Ministry of Health Fondos de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01335), the Spanish Ministry of the Economy Industry and Competitiveness (DEP2016-78377-R), and European Regional Development Funds (Una Manera de Hacer Europa). Support was also provided by the Regional Government of Navarra’s Department of Economic Development (0011-1365-2019-000152, 0011-1365-2020-000243), cofunded by European Regional Development Funds (ERDF 2014-2020 for Navarra). C.C.-S. is supported by the Spanish Ministry of Science and Innovation (FJC2018-037925-I). M.M. is supported by Junta de Andalucía and European Union (SNGJ Ref-8025). M.O. is supported by the Spanish Ministry of Economy and Competitiveness (BES-2017-080770). This study was supported by the University of Granada Plan Propio de Investigación 2021—Excellence Actions: Unit of Excellence on Exercise, Nutrition and Health (UCEENS)—and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, European Regional Development Funds (SOMM17/6107/UGR). ...Lisenssi
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Effects of a Family-Based Lifestyle Intervention Plus Supervised Exercise Training on Abdominal Fat Depots in Children With Overweight or Obesity
Cadenas-Sanchez, Cristina; Cabeza, Rafael; Idoate, Fernando; Osés, Maddi; Medrano, María; Villanueva, Arantxa; Arenaza, Lide; Sanz, Aritz; Ortega, Francisco B.; Ruiz, Jonatan R.; Labayen, Idoia (American Medical Association, 2022)Importance Excess abdominal fat is a major determinant in the development of insulin resistance and other metabolic disorders. Increased visceral adipose tissue (VAT) seems to precede the development of insulin resistance ... -
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