Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases : the HUNT study
Tynkkynen, N. P., Törmäkangas, T., Palviainen, T., Hyvärinen, M., Klevjer, M., Joensuu, L., Kujala, U., Kaprio, J., Bye, A., & Sillanpää, E. (2023). Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases : the HUNT study. European Journal of Epidemiology, 38, 995-1008. https://doi.org/10.1007/s10654-023-01029-w
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European Journal of EpidemiologyAuthors
Date
2023Discipline
Gerontologia ja kansanterveysLiikuntalääketiedeHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthSports and Exercise MedicineSchool of WellbeingCopyright
© The Author(s) 2023
Physical activity (PA), aerobic fitness, and cardiometabolic diseases (CMD) are highly heritable multifactorial phenotypes. Shared genetic factors may underlie the associations between higher levels of PA and better aerobic fitness and a lower risk for CMDs. We aimed to study how PA genotype associates with self-reported PA, aerobic fitness, cardiometabolic risk factors and diseases. PA genotype, which combined variation in over one million of gene variants, was composed using the SBayesR polygenic scoring methodology. First, we constructed a polygenic risk score for PA in the Trøndelag Health Study (N = 47,148) using UK Biobank single nucleotide polymorphism-specific weights (N = 400,124). The associations of the PA PRS and continuous variables were analysed using linear regression models and with CMD incidences using Cox proportional hazard models. The results showed that genotypes predisposing to higher amount of PA were associated with greater self-reported PA (Beta [B] = 0.282 MET-h/wk per SD of PRS for PA, 95% confidence interval [CI] = 0.211, 0.354) but not with aerobic fitness. These genotypes were also associated with healthier cardiometabolic profile (waist circumference [B = -0.003 cm, 95% CI = -0.004, -0.002], body mass index [B = -0.002 kg/m2, 95% CI = -0.004, -0.001], high-density lipoprotein cholesterol [B = 0.004 mmol/L, 95% CI = 0.002, 0.006]) and lower incidence of hypertensive diseases (Hazard Ratio [HR] = 0.97, 95% CI = 0.951, 0.990), stroke (HR = 0.94, 95% CI = 0.903, 0.978) and type 2 diabetes (HR = 0.94, 95 % CI = 0.902, 0.970). Observed associations were independent of self-reported PA. These results support earlier findings suggesting small pleiotropic effects between PA and CMDs and provide new evidence about associations of polygenic inheritance of PA and intermediate cardiometabolic risk factors.
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SpringerISSN Search the Publication Forum
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https://converis.jyu.fi/converis/portal/detail/Publication/184290391
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Research Council of FinlandFunding program(s)
Academy Research Fellow, AoF; Research costs of Academy Research Fellow, AoFAdditional information about funding
Open Access funding provided by University of Jyväskylä (JYU). This study is a part of the GenActive project which is funded by the Academy of Finland (341750, 346509 to E.S.), Juho Vainio Foundation (E.S.) and Päivikki and Sakari Sohlberg foundation (E.S.).License
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