Mortality associations with DNA methylation-based biological aging and physical functioning measures across a 20-year follow-up period
Föhr, T., Waller, K., Viljanen, A., Rantanen, T., Kaprio, J., Ollikainen, M., & Sillanpää, E. (2023). Mortality associations with DNA methylation-based biological aging and physical functioning measures across a 20-year follow-up period. Journals of Gerontology Series A : Biological Sciences and Medical Sciences, 78(8), 1489-1496. https://doi.org/10.1093/gerona/glad026
Authors
Date
2023Discipline
LiikuntalääketiedeGerontologia ja kansanterveysSports and Exercise MedicineGerontology and Public HealthCopyright
© 2023 the Authors
Background
Measures of biological aging range from DNA methylation (DNAm)-based estimates to measures of physical abilities. The purpose of this study was to compare DNAm- and physical functioning-based measures of biological aging in predicting mortality.
Methods
We studied 63- to 76-year-old women (N = 395) from the Finnish Twin Study on Aging (FITSA). Participants’ biological age (epigenetic clocks DNAm GrimAge and DunedinPACE) was estimated using blood DNAm data. Tests of physical functioning conducted under standardized laboratory conditions included the Timed Up and Go (TUG) test and 10-m walk test. Mortality hazard ratios (HRs) were calculated per every one standard deviation (SD) increase in the predictor. Cox regression models were conducted for individuals and twin pairs, the latter controlling for underlying genetic effects. The models were adjusted for known lifestyle predictors of mortality.
Results
During the follow-up period (mean 17.0 years, range 0.2–20.3), 187 participants died. In both the individual-based and pairwise analyses, GrimAge and both functional biomarkers of aging were associated with mortality independent of family relatedness, chronological age, physical activity, body mass index, smoking, education, or chronic diseases. In a model including both the DNAm-based measures and functional biomarkers of aging, GrimAge and TUG remained predictive.
Conclusions
The findings suggest that DNAm GrimAge and the TUG test are strong predictors of mortality independent of each other’s and genetic influences. DNAm-based measures and functional tests capture different aspects of the aging process and thus complement each other as measures of biological aging in predicting mortality.
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Publisher
Oxford University Press (OUP)ISSN Search the Publication Forum
1079-5006Keywords
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https://converis.jyu.fi/converis/portal/detail/Publication/176438294
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- Liikuntatieteiden tiedekunta [3150]
Related funder(s)
Research Council of FinlandFunding program(s)
Research costs of Academy Research Fellow, AoF; Academy Research Fellow, AoFAdditional information about funding
This work was supported by the Academy of Finland (grant 251723 to T.R., grants 265240, 263278, 308248, 312073, 336823 to J.K., 297908 and 251316 to M.O., 341750, 346509 to E.S.), EC MC ITN Project EPITRAIN (J.K. and M.O.), University of Helsinki Research Funds (M.O.), the Sigrid Juselius Foundation (to J.K. and M.O.), the Juho Vainio Foundation (T.F. and E.S.), the Päivikki and Sakari Sohlberg foundation (E.S.), and the Yrjö Jahnsson Foundation (E.S.). ...License
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