Physical activity, morbidity and mortality in twins: a 24-year prospective follow-up
Waller, K., Kujala, U., Rantanen, T., Kauppinen, M., Silventoinen, K., Koskenvuo, M., & Kaprio, J. (2010). Physical activity, morbidity and mortality in twins: a 24-year prospective follow-up. Eur J Epidemiol, 25, 731-739. https://doi.org/10.1007/s10654-010-9493-x
Published inEur J Epidemiol
DisciplineGerontologia ja kansanterveysLiikuntalääketiedeGerontology and Public HealthSports and Exercise Medicine
© Springer Science+Business Media B.V. 2010. This is a final draft version of an article whose final and definitive form has been published by Springer. Published in this repository with the kind permission of the publisher.
The aim of this study was to find out whether persistent leisure-time physical activity, adjusted for genetic liability and childhood experiences, protect against occurrence of specific chronic diseases and all-cause mortality. Study design was a 24-year prospective follow-up after 6-year physical activity discordance in twin pairs. From 5,663 healthy adult twin pairs, 146 pairs (including 29 mozygotic) discordant for both intensity and volume of leisure physical activity at baseline in both 1975 and 1981 were systematically identified. Mortality and occurrence of chronic diseases (diabetes, hypertension, coronary heart disease defined according to reimbursable medication status) were followed for the period 1.1.1983–31.12.2006 for mortality and 1.1.1983–31.12.2004 for diseases. By end of follow-up, 19 inactive and 10 active co-twins had died. In the whole sample, HR of death adjusted for social class was 2.08 (95% CI 1.06–4.09) for inactive vs. active co-twins, the HR being 2.67 (95% CI 1.15–6.20) among DZ pairs with no mortality difference among the smaller number of discordant MZ pairs. The reimbursable medication analyses showed a tendency of higher risk for inactive vs. active co-twins. Among DZ pairs, HR of diabetes medication adjusted for social class was 2.73 (95% CI 0.62–12.00) and HR of hypertension medication was 2.14 (95% CI 0.94–4.89). This study supports the earlier findings that physical activity is associated with reduced mortality. However the difference was seen only in DZ pairs and therefore some residual genetic confounding effects on mortality cannot be excluded. ...
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Showing items with similar title or keywords.
Waller, Katja (University of Jyväskylä, 2011)
Work ability in midlife as a predictor of mortality and disability in later life: a 28-year prospective follow-up study von Bonsdorff, Mikaela; Seitsamo, Jorma; Ilmarinen, Juhani; Nygård, Clas-Håkan; von Bonsdorff, Monika; Rantanen, Taina (Canadian medical association, 2011)Background: Poor work ability correlates with increased morbidity and early retirement from the workforce, but the association in old age is not known. We investigated work ability in midlife among white-collar and ...
Physical heaviness of work and sitting at work as predictors of mortality : a 26-year follow-up of the Helsinki Birth Cohort Study Mikkola, Tuija M.; von Bonsdorff, Mikaela; Salonen, Minna K.; Kautiainen, Hannu; Ala-Mursula, Leena; Solovieva, Svetlana; Viikari-Juntura, Eira; Eriksson, Johan G. (BMJ Publishing Group, 2019)Objectives: To examine the relationships of late-career physical heaviness of work and sitting at work with mortality. A national-level job exposure matrix was used to determine the occupation-specific level of ...
Äijö, Marja; Kauppinen, Markku; Kujala, Urho; Parkatti, Terttu (Elsevier; Shanghai University of Sport, 2016)Background: Little is known about change in physical activity (PA) and its relationship to all-cause mortality among old people. There is even less information about the association between PA, fitness, and all-cause ...
Mortality Risk among Older People Who Did Versus Did Not Sustain a Fracture : Baseline Prefracture Strength and Gait Speed as Predictors in a 15-Year Follow-Up Koivunen, Kaisa; Sillanpää, Elina; von Bonsdorff, Mikaela; Sakari, Ritva; Törmäkangas, Timo; Rantanen, Taina (Oxford University Press; The Gerontological Society of America, 2020)BACKGROUND: Physiological reserve, as indicated by muscle strength and gait speed, may be especially determinant of survival in people who are exposed to a health stressor. We studied whether the association between ...