Prenatal thyroid hormones accelerate postnatal growth and telomere shortening in wild great tits
Hsu, B.-Y., Cossin-Sevrin, N., Stier, A., & Ruuskanen, S. (2023). Prenatal thyroid hormones accelerate postnatal growth and telomere shortening in wild great tits. Journal of Experimental Biology, 226(6), Article jeb243875. https://doi.org/10.1242/jeb.243875
Julkaistu sarjassa
Journal of Experimental BiologyPäivämäärä
2023Tekijänoikeudet
© 2023. Published by The Company of Biologists Ltd.
Early-life environment is known to affect later-life health and disease, which could be
mediated by the early-life programming of telomere length, a key hallmark of ageing.
According to the fetal programming of telomere biology hypothesis, variation in prenatal
exposure to hormones is likely to influence telomere length. Yet the contribution of key
metabolic hormones, i.e. thyroid hormones (THs), has been largely ignored. We recently
showed that in contrast to predictions, exposure to elevated prenatal THs increased
postnatal telomere length in wild collared flycatchers, but the generality of such effect, its
underlying proximate mechanisms and consequences on survival have not been
investigated. We therefore conducted a comprehensive study evaluating the impact of THs
on potential drivers of telomere dynamics (growth, post-natal THs, mitochondria and
oxidative stress), telomere length and medium-term survival using wild great tits as a model
system. While prenatal THs did not significantly affect telomere length a week after hatching
(i.e. day 7), they influenced postnatal telomere shortening (i.e. shorter telomeres at day 14
and the following winter) but not apparent survival. Circulating THs, mitochondrial density or
oxidative stress biomarkers were not significantly influenced, whereas TH-supplemented
group showed accelerated growth, which may explain the observed delayed effect on
telomeres. We discuss several alternative hypotheses that may explain the contrast with our
previous findings in flycatchers. Given that shorter telomeres in early life tend to be carried
until adulthood and are often associated with decreased survival prospects, the effects of
prenatal THs on telomeres may have long-lasting effects on senescence.
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https://converis.jyu.fi/converis/portal/detail/Publication/176730886
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This study was financially supported by the Academy of Finland (#286278 to SR). NCS acknowledges support from the EDUFI Fellowship and Maupertuis Grant. B-Y.H work was supported by grants from the Ella and Georg Ehrnrooth Foundation and Academy of Finland (#332716). AS was supported by a ‘Turku Collegium for Science and Medicine’ Fellowship and a Marie Sklodowska-Curie Postdoctoral Fellowship (#894963) at the time of writing.![showless](/themes/JYX2//images/showless.png)
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