Developmental plasticity of mitochondrial aerobic metabolism, growth and survival by prenatal glucocorticoids and thyroid hormones : an experimental test in wild great tits
Cossin-Sevrin, N., Hsu, B.-Y., Marciau, C., Viblanc, V. A., Ruuskanen, S., & Stier, A. (2022). Developmental plasticity of mitochondrial aerobic metabolism, growth and survival by prenatal glucocorticoids and thyroid hormones : an experimental test in wild great tits. Journal of Experimental Biology, 225(9), Article jeb243414. https://doi.org/10.1242/jeb.243414
Julkaistu sarjassa
Journal of Experimental BiologyTekijät
Päivämäärä
2022Tekijänoikeudet
© 2022. Published by The Company of Biologists Ltd.
Developmental plasticity is partly mediated by transgenerational effects, including those mediated by the maternal endocrine system. Glucocorticoid and thyroid hormones may play central roles in developmental programming through their action on metabolism and growth. However, the mechanisms by which they affect growth and development remain understudied. One hypothesis is that maternal hormones directly affect the production and availability of energy-carrying molecules (e.g. ATP) by their action on mitochondrial function. To test this hypothesis, we experimentally increased glucocorticoid and thyroid hormones in wild great tit eggs (Parus major) to investigate their impact on offspring mitochondrial aerobic metabolism (measured in blood cells), and subsequent growth and survival. We show that prenatal glucocorticoid supplementation affected offspring cellular aerobic metabolism by decreasing mitochondrial density, maximal mitochondrial respiration and oxidative phosphorylation, while increasing the proportion of the maximum capacity being used under endogenous conditions. Prenatal glucocorticoid supplementation only had mild effects on offspring body mass, size and condition during the rearing period, but led to a sex-specific (females only) decrease in body mass a few months after fledging. Contrary to our expectations, thyroid hormones supplementation did not affect offspring growth or mitochondrial metabolism. Recapture probabilities as juveniles or adults were not significantly affected by prenatal hormonal treatments. Our results demonstrate that prenatal glucocorticoids can affect post-natal mitochondrial density and aerobic metabolism. The weak effects on growth and apparent survival suggest that nestlings were mostly able to compensate for the transient decrease in mitochondrial aerobic metabolism induced by prenatal glucocorticoids.
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Julkaisija
The Company of BiologistsISSN Hae Julkaisufoorumista
0022-0949Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/118846791
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Lisätietoja rahoituksesta
Funder(s): Horizon 2020 Framework Programme, Award Id(s): 894963 Funder(s): Academy of Finland, Award Id(s): 286278Lisenssi
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