Probing the Gelation Synergies and Anti-Escherichia coli Activity of Fmoc-Phenylalanine/Graphene Oxide Hybrid Hydrogel
Sitsanidis, E. D., A. L. Dutra, L., Schirmer, J., Chevigny, R., Lahtinen, M., Johansson, A., Piras, C. C., Smith, D. K., Tiirola, M., Pettersson, M., & Nissinen, M. (2023). Probing the Gelation Synergies and Anti-Escherichia coli Activity of Fmoc-Phenylalanine/Graphene Oxide Hybrid Hydrogel. ACS Omega, 8(11), 10225-10234. https://doi.org/10.1021/acsomega.2c07700
Published inACS Omega
DisciplineYmpäristötiedeNanoscience CenterEpäorgaaninen kemiaSolu- ja molekyylibiologiaFysikaalinen kemiaOrgaaninen kemiaEpäorgaaninen ja analyyttinen kemiaResurssiviisausyhteisöEnvironmental ScienceNanoscience CenterInorganic ChemistryCell and Molecular BiologyPhysical ChemistryOrganic ChemistryInorganic and Analytical ChemistrySchool of Resource Wisdom
© 2023 the Authors
The N-fluorenyl-9-methyloxycarbonyl (Fmoc)-protected amino acids have shown high antimicrobial application potential, among which the phenylalanine derivative (Fmoc-F) is the most well-known representative. However, the activity spectrum of Fmoc-F is restricted to Gram-positive bacteria only. The demand for efficient antimicrobial materials expanded research into graphene and its derivatives, although the reported results are somewhat controversial. Herein, we combined graphene oxide (GO) flakes with Fmoc-F amino acid to form Fmoc-F/GO hybrid hydrogel for the first time. We studied the synergistic effect of each component on gelation and assessed the material’s bactericidal activity on Gram-negative Escherichia coli (E. coli). GO flakes do not affect Fmoc-F self-assembly per se but modulate the elasticity of the gel and speed up its formation. The hybrid hydrogel affects E. coli survival, initially causing abrupt bacterial death followed by the recovery of the surviving ones due to the inoculum effect (IE). The combination of graphene with amino acids is a step forward in developing antimicrobial gels due to their easy preparation, chemical modification, graphene functionalization, cost-effectiveness, and physicochemical/biological synergy of each component. ...
PublisherAmerican Chemical Society (ACS)
ISSN Search the Publication Forum2470-1343
Publication in research information system
MetadataShow full item record
Additional information about fundingThe authors would like to acknowledge the Jane and Aatos Erkko foundation for supporting the current work.
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