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dc.contributor.authorHaapanen, Markus J.
dc.contributor.authorMikkola, Tuija M.
dc.contributor.authorKortelainen, Lauri
dc.contributor.authorJylhävä, Juulia
dc.contributor.authorWasenius, Niko S.
dc.contributor.authorKajantie, Eero
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorvon Bonsdorff, Mikaela B.
dc.date.accessioned2022-12-15T08:03:23Z
dc.date.available2022-12-15T08:03:23Z
dc.date.issued2023
dc.identifier.citationHaapanen, M. J., Mikkola, T. M., Kortelainen, L., Jylhävä, J., Wasenius, N. S., Kajantie, E., Eriksson, J. G., & von Bonsdorff, M. B. (2023). Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age : A Longitudinal Birth Cohort Study. <i>Journals of Gerontology Series A: Biological Sciences and Medical Sciences</i>, <i>78</i>(6), 980-987. <a href="https://doi.org/10.1093/gerona/glac233" target="_blank">https://doi.org/10.1093/gerona/glac233</a>
dc.identifier.otherCONVID_160420044
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/84399
dc.description.abstractBackground Body mass index (BMI) may not be an optimal predictor of frailty as its constituents, lean and fat mass, may have opposite associations with frailty. Methods A linear mixed model analysis was performed in the Helsinki Birth Cohort Study (n=2000) spanning from 57 to 84 years. A 39-item frailty index (FI) was calculated on three occasions over 17 years. Body composition in late midlife included BMI, percent body fat (%BF), waist-to-hip ratio (WHR), lean mass index (LMI), and fat mass index (FMI). Results Mean FI levels increased by 0.28%/year among men and by 0.34%/year among women. Among women, per each kg/m 2 higher BMI and each unit higher %BF the increases in FI levels per year were 0.013 percentage points (PP) steeper (95% CI=0.004, 0.023) and 0.009 PP steeper (95% CI=0.002, 0.016) from late midlife into old age. Among men, per each 0.1-unit greater WHR the increase in FI levels was 0.074 PP steeper per year (95% CI=-0.0004, 0.148). Cross-sectionally, greater FMI and LMI in late midlife were associated with higher FI levels but the direction of the association regarding LMI changed after adjustment for FMI. The categories ‘high FMI & high LMI’ and ‘high FMI & low LMI’ showed the highest FI levels relative to the category ‘low FMI & low LMI’. Conclusions In late midlife, greater adiposity (%BF) among women and abdominal obesity (WHR) among men may predispose to higher levels of frailty from late midlife into old age. Greater lean mass alone may be protective of frailty, but not in the presence of high fat mass.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.relation.ispartofseriesJournals of Gerontology Series A: Biological Sciences and Medical Sciences
dc.rightsCC BY 4.0
dc.subject.otherbody composition
dc.subject.otherfrailty
dc.subject.otherrisk factor
dc.subject.otherlife-course
dc.titleBody Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age : A Longitudinal Birth Cohort Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202212155654
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange980-987
dc.relation.issn1079-5006
dc.relation.numberinseries6
dc.relation.volume78
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber349336
dc.subject.ysokehonkoostumus
dc.subject.ysoriskitekijät
dc.subject.ysogerastenia
dc.subject.ysoelämänkaari
dc.subject.ysoruumis
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p26989
jyx.subject.urihttp://www.yso.fi/onto/yso/p13277
jyx.subject.urihttp://www.yso.fi/onto/yso/p28376
jyx.subject.urihttp://www.yso.fi/onto/yso/p3313
jyx.subject.urihttp://www.yso.fi/onto/yso/p4005
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1093/gerona/glac233
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundinginformationThis work was supported by Medicinska Understödföreningen Liv och Hälsa, Finska Läkaresällskapet, and the Academy of Finland grant no. 349336.
dc.type.okmA1


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